Authors
Anthony E Lang, Andres M Lozano
Publication date
1998/10/15
Source
New England Journal of Medicine
Volume
339
Issue
16
Pages
1130-1143
Publisher
Massachusetts Medical Society
Description
Pathophysiology
The establishment of a model of parkinsonism through the administration of MPTP to nonhuman primates has provided important insights into new therapeutic strategies. A typical parkinsonian syndrome develops in the animals that is characterized by dopaminergic-cell loss in the substantia nigra and striking abnormalities in the spontaneous activity and sensorimotor responses of neurons in the basal ganglia.94,95 A fundamental discovery has been that the dopamine-deficiency state is associated with increased activity of the inhibitory γ-aminobutyric acid (GABA)–employing (GABAergic) output nuclei in the basal ganglia, the internal segment of the globus pallidus, and the pars reticulata of the substantia . . .
Total citations
Scholar articles
AE Lang, AM Lozano - New England Journal of Medicine, 1998
AE Lang, AM Lozano - New England Journal of Medicine, 1998
AE Lang, AM Lozano - New England Journal of Medicine-Unbound Volume, 1998
AE Lang, AM Lozano, Parkinson's disease - N. Engl. J. Med., 1998