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This paper deals with the problem of the re-use of derelict buildings. The main objective of the research is to rank the available building's regeneration alternatives from the multiple-criteria sustainability approach, by combining the economic benefits of the regeneration of buildings with the environmental potential as well as the social interest. A case study is presented and regeneration problems relating to derelict and mismanaged buildings in Lithuanian rural areas are analysed by means of multi-criterion decision-making techniques. The criteria are based on sustainability indicators and represent three typological groups in sustainable decision-making, as proposed by the authors in previous research and which include the current state of abandoned buildings and their environment, regeneration possibilities and the environmental impact of the implementation of a particular redevelopment alternative. Because …