Authors
Martijn P Van Den Heuvel, Karina J Kersbergen, Marcel A De Reus, Kristin Keunen, René S Kahn, Floris Groenendaal, Linda S De Vries, Manon JNL Benders
Publication date
2015/9/1
Journal
Cerebral cortex
Volume
25
Issue
9
Pages
3000-3013
Publisher
Oxford University Press
Description
The human connectome is the result of an elaborate developmental trajectory. Acquiring diffusion-weighted imaging and resting-state fMRI, we studied connectome formation during the preterm phase of macroscopic connectome genesis. In total, 27 neonates were scanned at week 30 and/or week 40 gestational age (GA). Examining the architecture of the neonatal anatomical brain network revealed a clear presence of a small-world modular organization before term birth. Analysis of neonatal functional connectivity (FC) showed the early formation of resting-state networks, suggesting that functional networks are present in the preterm brain, albeit being in an immature state. Moreover, structural and FC patterns of the neonatal brain network showed strong overlap with connectome architecture of the adult brain (85 and 81%, respectively). Analysis of brain development between week 30 and week 40 GA …
Total citations
20142015201620172018201920202021202220232024725234136413743373825
Scholar articles
MP Van Den Heuvel, KJ Kersbergen, MA De Reus… - Cerebral cortex, 2015