Authors
N Morikawa, M Naoi, W Maruyama, S Ohta, Y Kotake, H Kawai, T Niwa, P Dostert, Y Mizuno
Publication date
1998/9
Journal
Journal of neural transmission
Volume
105
Pages
677-688
Publisher
Springer-Verlag
Description
We report effect of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes. Generally these compounds were potent inhibitors of NADH-linked mitochondrial state 3 respiration and complex I. Presence of a phenyl group at the C1 position or oxidation of N-methylated isoquinones into N-methylisoquinolinium ion augmented the potency to inhibit mitochondrial respiration and complex I. Many of these compounds have been identified in human brains. In view of the mitochondrial and oxidative stress hypothesis, our results suggest involvement of these neurotoxins as potential causes of mitochondrial failure in Parkinson's disease.
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Scholar articles
N Morikawa, M Naoi, W Maruyama, S Ohta, Y Kotake… - Journal of neural transmission, 1998