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East Tibet preserves broad areas of low relief that occur at elevations >3000 m and are dissected by major strike-slip faults that have been repeatedly reactivated since the late Mesozoic. Apatite fission-track samples from these low-relief, high-elevation surfaces indicate Cretaceous cooling (ca. 90 Ma). Fast rock uplift of the 110 °C isotherm and a fossilized partial annealing zone began in the plateau interior of east Tibet in the Miocene. Low denudation rates in the plateau interior during the Cenozoic, which are constrained by thermal history modeling and a consistency in ages from apatite fission tracks, suggest that dip-slip displacement on faults has been minor. Some localized areas have experienced the effects of structurally enhanced rock uplift and denudation or fault-related hydrothermal reheating. Cooling ages in Eocene sediments deposited on the older plateau surface suggest that rapid denudation …