Authors
Michele Malaguarnera, Marco Vacante, Tijana Antic, Maria Giordano, Giuseppe Chisari, Rosaria Acquaviva, Silvana Mastrojeni, Giulia Malaguarnera, Antonio Mistretta, Giovanni Li Volti, Fabio Galvano
Publication date
2012/2
Journal
Digestive diseases and sciences
Volume
57
Pages
545-553
Publisher
Springer US
Description
Background
Increased exposure to intestinal bacterial products may contribute to the pathogenesis of non alcoholic steatohepatitis (NASH). Bifidobacteria are predominant bacterial species in the human gut microbiota and have been considered to exert a beneficial effect on human health by maintaining the equilibrium of the resident microbiota.
Aims
To evaluate the effects of Bifidobacterium longum with fructo-oligosaccharides (Fos) in the treatment of NASH.
Methods
A total of 66 patients were randomly and equally divided into two groups receiving Bifidobacterium longum with Fos and lifestyle modification (i.e., diet and exercise) versus lifestyle modification alone. The following variables were assessed at −4 (beginning of the dietary lead-in period), 0 (randomization), 6, 12, 18, and 24 weeks: aspartate transaminase …
Total citations
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Scholar articles
M Malaguarnera, M Vacante, T Antic, M Giordano… - Digestive diseases and sciences, 2012