Authors
Renz CW Klomberg, Hella C van der Wal, Martine A Aardoom, Polychronis Kemos, Dimitris Rizopoulos, Frank M Ruemmele, Mohammed Charrout, Hankje C Escher, Nicholas M Croft, Lissy de Ridder, PIBD-SETQuality collaborative group Milovanovich Ivan D Ashton James J Henderson Paul Ledder Oren de Meij Tim GJ Hansen Richard Hummel Thalia Z Arai Katsuhiro Rodrigues Astor Cameron Fiona Koletzko Sibylle Muhammed Rafeeq Nedelkopoulou Natalia
Publication date
2024/5/1
Journal
Journal of Crohn's and Colitis
Volume
18
Issue
5
Pages
738-750
Publisher
Oxford University Press
Description
Background and Aims
Treatment guidelines for paediatric Crohn’s disease [CD] suggest early use of anti-tumour necrosis factor alpha [anti-TNFα] in high-risk individuals. The aim is to evaluate the effect of early anti-TNF in a real-world cohort.
Methods
Children with newly diagnosed CD were prospectively recruited at 28 participating sites of the international observational PIBD-SETQuality study. Outcomes were compared at 3 months, 1 and 2 years between patients receiving early anti-TNF [<90 days after diagnosis] and those not receiving early anti-TNF. Outcomes included sustained steroid-free remission [SSFR] without treatment intensification [specified as SSFR*] and sustained steroid-free mild/inactive disease without treatment intensification [specified as SSFMI*]. Penalised logistic regression model-based standardisation was applied to estimate the relative risks [RR] of …
Total citations
20242
Scholar articles
RCW Klomberg, HC van der Wal, MA Aardoom… - Journal of Crohn's and Colitis, 2024