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Disruption of the gut microbiome has been widely reported in inflammatory bowel disease (IBD), particularly reduced bacterial diversity. Determining the role of this in IBD onset is hampered by a paucity of studies in newly diagnosed disease. We present outputs from a systematic review of the microbiome in pre-treatment IBD.

We searched MEDLINE, Embase between inception and December 2022 for any study presenting microbial analysis of patients diagnosed with IBD in the pre-treatment phase. All screening and extractions were done independently in duplicate. Data extracted included all measures of microbial diversity, the source of samples, any reported controls and clinical/patient parameters. Where appropriate, we performed random-effects meta-analysis of standardised mean difference, reporting 95% CI values and sub-grouped by type of IBD.

10,805 abstracts were …