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Sa1885 THE LONGITUDINAL ANALYSIS OF FECAL MICROBIOTA IN RESPONCE TO USTEKINUMAB TREATMENT IN PATIENTS WITH CROHN'S DISEASE Jeongseok Kim, Min Kyu Kim, A-Ran Yoon, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye Background Emerging evidence supports that treatment of Crohn’ s disease (CD) can alter the intestinal microbiota, which can play a significant role in the pathogenesis and therapeutic outcomes of CD. Ustekinumab (UST) has also been reported to modify the intestinal microbiota during a short-term treatment period. However, the long-term impact of UST treatment on the intestinal microbiota has rarely been studied. Methods We prospectively enrolled patients with CD who were planning to start UST treatment and collected fecal samples before (baseline) and …