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The circular economy is a holistic approach aimed at creating a sustainable and regenerative economic system that minimizes waste, promotes resource efficiency, and fosters environmental preservation. Precision biotechnology, specifically the utilization of beneficial microbes, has emerged as a fundamental approach in advancing the circular economy. This chapter explores how beneficial microbes, harnessed through precision biotechnology, play a pivotal role in transforming various sectors of the economy by promoting sustainable practices, enhancing resource utilization, and contributing to a more resilient and eco-friendly future.