Authors
Danielle Ní Chróinín, Kjell Asplund, Signild Åsberg, Elizabeth Callaly, Elisa Cuadrado-Godia, Exuperio Díez-Tejedor, Mario Di Napoli, Stefan T Engelter, Karen L Furie, Sotirios Giannopoulos, Antonio M Gotto Jr, Niamh Hannon, Fredrik Jonsson, Moira K Kapral, Joan Martí-Fàbregas, Patricia Martínez-Sánchez, Haralampos J Milionis, Joan Montaner, Antonio Muscari, Slaven Pikija, Jeffrey Probstfield, Natalia S Rost, Amanda G Thrift, Konstantinos Vemmos, Peter J Kelly
Publication date
2013/2
Source
Stroke
Volume
44
Issue
2
Pages
448-456
Publisher
Lippincott Williams & Wilkins
Description
Background and Purpose
Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke.
Methods
The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (≤72 hours after stroke), and (2) thrombolysis-treated patients.
Results
The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95% confidence interval [CI], 1.29–1.56; P<0.001), but not 1 …
Scholar articles
D Ní Chróinín, K Asplund, S Åsberg, E Callaly… - Stroke, 2013