Authors
Stuart Kauffman, Carsten Peterson, Björn Samuelsson, Carl Troein
Publication date
2003/12/9
Journal
Proceedings of the National Academy of Sciences
Volume
100
Issue
25
Pages
14796-14799
Publisher
National Academy of Sciences
Description
The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean networks. We find that, for ensembles of generated models, those with canalyzing Boolean rules are remarkably stable, whereas those with random Boolean rules are only marginally stable. Furthermore, substantial parts of the generated networks are frozen, in the sense that they reach the same state, regardless of initial state. Thus, our ensemble approach suggests that the yeast network shows highly ordered dynamics.
Total citations
20042005200620072008200920102011201220132014201520162017201820192020202120222023202463635404235345240455328413545342424232318
Scholar articles
S Kauffman, C Peterson, B Samuelsson, C Troein - Proceedings of the National Academy of Sciences, 2003