Authors
Robert W Cox, Gang Chen, Daniel R Glen, Richard C Reynolds, Paul A Taylor
Publication date
2017/4/1
Journal
Brain connectivity
Volume
7
Issue
3
Pages
152-171
Publisher
Mary Ann Liebert, Inc.
Description
Recent reports of inflated false-positive rates (FPRs) in FMRI group analysis tools by Eklund and associates in 2016 have become a large topic within (and outside) neuroimaging. They concluded that existing parametric methods for determining statistically significant clusters had greatly inflated FPRs (“up to 70%,” mainly due to the faulty assumption that the noise spatial autocorrelation function is Gaussian shaped and stationary), calling into question potentially “countless” previous results; in contrast, nonparametric methods, such as their approach, accurately reflected nominal 5% FPRs. They also stated that AFNI showed “particularly high” FPRs compared to other software, largely due to a bug in 3dClustSim. We comment on these points using their own results and figures and by repeating some of their simulations. Briefly, while parametric methods show some FPR inflation in those tests (and assumptions of …
Total citations
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Scholar articles
RW Cox, G Chen, DR Glen, RC Reynolds, PA Taylor - Brain connectivity, 2017