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With the increasing use of wireless capsule endoscopy (WCE) devices in healthcare, it is of utmost importance to analyze the electromagnetic power absorption and thermal effects caused by in-body propagation of wireless signals from these devices. This paper studies the path loss, specific absorption rate (SAR), specific absorption (SA), and temperature variation of the human body caused by an impulse-radio ultra-wideband (UWB) based WCE operating inside the human abdomen. In addition, the design and in-body performance of an UWB antenna with dimensions of 11.85×9×1.27 mm and operating from 3.5 to 4.5 GHz is described in this paper. Path loss is evaluated using both experimental and simulation based methods to characterize the in-body propagation channel. The experimental setup uses a pig's abdominal tissue samples to demonstrate the propagation characteristics of human tissue while a …