Authors
Hooman Mirzakhani, Augusto A Litonjua, Thomas F McElrath, George O’Connor, Aviva Lee-Parritz, Ronald Iverson, George Macones, Robert C Strunk, Leonard B Bacharier, Robert Zeiger, Bruce W Hollis, Diane E Handy, Amitabh Sharma, Nancy Laranjo, Vincent Carey, Weilliang Qiu, Marc Santolini, Shikang Liu, Divya Chhabra, Daniel A Enquobahrie, Michelle A Williams, Joseph Loscalzo, Scott T Weiss
Publication date
2016/12/1
Journal
The Journal of clinical investigation
Volume
126
Issue
12
Pages
4702-4715
Publisher
American Society for Clinical Investigation
Description
BACKGROUND. Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia.
METHODS. We assessed the effect of vitamin D supplementation (4,400 vs. 400 IU/day), initiated early in pregnancy (10–18 weeks), on the development of preeclampsia. The effects of serum vitamin D (25-hydroxyvitamin D [25OHD]) levels on preeclampsia incidence at trial entry and in the third trimester (32–38 weeks) were studied. We also conducted a nested case-control study of 157 women to investigate peripheral blood vitamin D–associated gene expression profiles at 10 to 18 weeks in 47 participants who developed preeclampsia.
RESULTS. Of 881 women randomized, outcome data were available for 816, with 67 (8.2%) developing preeclampsia. There was no significant difference between treatment (N = 408) or control (N = 408) groups in the incidence of preeclampsia (8.08% vs. 8.33 …
Scholar articles
H Mirzakhani, AA Litonjua, TF McElrath, G O'Connor… - The Journal of clinical investigation, 2016