Authors
Rubina Tabassum, Ganesh Chauhan, Om Prakash Dwivedi, Anubha Mahajan, Alok Jaiswal, Ismeet Kaur, Khushdeep Bandesh, Tejbir Singh, Benan John Mathai, Yogesh Pandey, Manickam Chidambaram, Amitabh Sharma, Sreenivas Chavali, Shantanu Sengupta, Lakshmi Ramakrishnan, Pradeep Venkatesh, Sanjay K Aggarwal, Saurabh Ghosh, Dorairaj Prabhakaran, Reddy K Srinath, Madhukar Saxena, Monisha Banerjee, Sandeep Mathur, Anil Bhansali, Viral N Shah, Sri Venkata Madhu, Raman K Marwaha, Analabha Basu, Vinod Scaria, Mark I McCarthy, Radha Venkatesan, Viswanathan Mohan, Nikhil Tandon, Dwaipayan Bharadwaj
Publication date
2013/3/1
Journal
Diabetes
Volume
62
Issue
3
Pages
977-986
Publisher
American Diabetes Association
Description
Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored but high-risk group. We identified a new type 2 diabetes–associated locus at 2q21, with the lead signal being rs6723108 (odds ratio 1.31; P = 3.32 × 10−9). Imputation analysis refined the signal to rs998451 (odds ratio 1.56; P = 6.3 × 10−12) within TMEM163 that encodes a probable vesicular transporter in nerve terminals. TMEM163 variants also showed association with decreased fasting plasma insulin and homeostatic model assessment of insulin resistance, indicating a plausible effect through impaired insulin secretion. The 2q21 region also harbors RAB3GAP1 and ACMSD; those are involved in neurologic disorders. Forty-nine of 56 previously reported signals showed consistency in …
Scholar articles
R Tabassum, G Chauhan, OP Dwivedi, A Mahajan… - Diabetes, 2013