Authors
Samuli Ripatti, Emmi Tikkanen, Marju Orho-Melander, Aki S Havulinna, Kaisa Silander, Amitabh Sharma, Candace Guiducci, Markus Perola, Antti Jula, Juha Sinisalo, Marja-Liisa Lokki, Markku S Nieminen, Olle Melander, Veikko Salomaa, Leena Peltonen, Sekar Kathiresan
Publication date
2010/10/23
Journal
The Lancet
Volume
376
Issue
9750
Pages
1393-1400
Publisher
Elsevier
Description
Background
Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide polymorphisms (SNPs) associated with coronary heart disease. We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design.
Methods
We tested 13 recently discovered SNPs for association with coronary heart disease in a case-control design including participants differing from those in the discovery samples (3829 participants with prevalent coronary heart disease and 48 897 controls free of the disease) and a prospective cohort design including 30 725 participants free of cardiovascular disease from Finland and Sweden. We modelled the 13 SNPs as a multilocus genetic risk score and used Cox proportional hazards models to estimate the association of genetic risk score with incident …
Total citations
Scholar articles
S Ripatti, E Tikkanen, M Orho-Melander, AS Havulinna… - The Lancet, 2010