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Oxidative DNA damage is the most frequent type of damage encountered by aerobic cells and may play an important role in biological processes such as mutagenesis, carcinogenesis and aging in humans. Oxidative damage generates a myriad of modifications in DNA. We investigated the cellular repair of DNA base damage products in DNA of cultured human lymphoblast cells, which were exposed to oxidative stress by H ₂ O ₂ . This DNA-damaging agent is known to cause base modifications in genomic DNA of mammalian cells [ Arch. Biochem. Biophys. 285, 388–390]. Following treatment with H ₂ O ₂ , the culture medium was freed from H ₂ O ₂ and cells were incubated for time periods ranging from 10 min to 6 h. DNA was isolated from control cells, hydrogen peroxide-treated cells and cells incubated …