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Effects of age, sex, race, and initial fitness on training responses of maximal O₂ uptake (V˙o _2 max) are unclear. Data were available on 435 whites and 198 blacks (287 men and 346 women), aged 17–65 yr, before and after standardized cycle ergometer training. Individual responses varied widely, butV˙o _2 max increased significantly for all groups. Responses by men and women and by blacks and whites of all ages varied widely. There was no sex difference for change (Δ) inV˙o _2 max(ml · kg⁻¹ · min⁻¹); women had lower initial values and greater relative (%) increases. Blacks began with lower values but had similar responses. Older subjects had a lower Δ but a similar percent change. BaselineV˙o _2 max correlated nonsignificantly with ΔV˙o _2 max but significantly with percent change. There were high, medium, and low responders in all age groups, both sexes, both races, and all levels of initial fitness …