Authors
Priya Duggal, Chloe L Thio, Genevieve L Wojcik, James J Goedert, Alessandra Mangia, Rachel Latanich, Arthur Y Kim, Georg M Lauer, Raymond T Chung, Marion G Peters, Gregory D Kirk, Shruti H Mehta, Andrea L Cox, Salim I Khakoo, Laurent Alric, Matthew E Cramp, Sharyne M Donfield, Brian R Edlin, Leslie H Tobler, Michael P Busch, Graeme Alexander, Hugo R Rosen, Xiaojiang Gao, Mohamed Abdel-Hamid, Richard Apps, Mary Carrington, David L Thomas
Publication date
2013/2/19
Journal
Annals of internal medicine
Volume
158
Issue
4
Pages
235-245
Publisher
American College of Physicians
Description
Chinese translation
Background
Hepatitis C virus (HCV) infections occur worldwide and either spontaneously resolve or persist and markedly increase the person's lifetime risk for cirrhosis and hepatocellular carcinoma. Although HCV persistence occurs more often in persons of African ancestry and persons with genetic variants near interleukin-28B (IL-28B), the genetic basis is not well-understood.
Objective
To evaluate the host genetic basis for spontaneous resolution of HCV infection.
Design
2-stage, genome-wide association study.
Setting
13 international multicenter study sites.
Patients
919 persons with serum HCV antibodies but no HCV RNA (spontaneous resolution) and 1482 persons with serum HCV antibodies and HCV RNA …
Total citations
Scholar articles
P Duggal, CL Thio, GL Wojcik, JJ Goedert, A Mangia… - Annals of internal medicine, 2013