Authors
Ashwin Balagopal, Frances H Philp, Jacquie Astemborski, Timothy M Block, Anand Mehta, Ronald Long, Gregory D Kirk, Shruti H Mehta, Andrea L Cox, David L Thomas, Stuart C Ray
Publication date
2008/7/1
Journal
Gastroenterology
Volume
135
Issue
1
Pages
226-233
Publisher
WB Saunders
Description
Background & Aims
Human immunodeficiency virus (HIV)-1 infection has been associated with enhanced microbial translocation, and microbial translocation is a mechanism through which alcohol and some enteric conditions cause liver disease. We hypothesized that HIV promotes liver disease by enhancing microbial translocation.
Methods
We studied human cohorts in which hepatitis C virus (HCV) and HIV outcomes were carefully characterized.
Results
HIV-related CD4+ lymphocyte depletion was strongly associated with microbial translocation as indicated by elevated levels of circulating lipopolysaccharide (LPS), LPS-binding protein, soluble CD14, and fucose-binding lectin (AAL) reactive to immunoglobulin G specific for the α-galactose epitope and suppressed levels of endotoxin core antibodies (EndoCAb IgM) in HIV-infected subjects compared with the same persons before they had HIV infection and …
Total citations
Scholar articles
A Balagopal, FH Philp, J Astemborski, TM Block… - Gastroenterology, 2008