Authors
CHRISTIAN P Larsen, PJ Morris, JM Austyn
Publication date
1990/1/1
Journal
The Journal of experimental medicine
Volume
171
Issue
1
Pages
307-314
Description
It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.
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Scholar articles
CP Larsen, PJ Morris, JM Austyn - The Journal of experimental medicine, 1990