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Femicide, the gender-related killing of women and girls, has received an unprecedented rise in international attention in the past decade, prompting increased discussions about how to define and measure femicide. Following a review of definitions and indicators, this article examines the utility of numerous sex/gender-related motives and indicators (SGRMIs) for distinguishing femicide from other homicides as well as the accessibility of these indicators in data sources typically accessed by social science researchers. Specifically, using a comprehensive database whose primary focus is femicide, the presence of SGRMIs in male-perpetrator/female-victim homicide – those killings most closely aligned with the concept of femicide – is compared to other perpetrator–victim gender combinations. Results show that multiple SGRMIs are more common in male-perpetrator/female-victim killings than other homicides …