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The present disclosure is generally related to the separation of liquids from solids and for the recovery of solids and/or liquids from slurries. In some embodiments, liquids are separated from solids by applying a reduced pressure. In some embodiments, slurries are flowed by applying a pres sure gradient. In some embodiments, an apparatus is pro vided that comprises a channel, an inlet, an outlet, and one or more ports. One or more ports may be constructed and arranged to apply a pressure differential and/or a reduced pressure to the channel. Such systems and methods may, in some embodiments, facilitate continuous manufacturing of solid products.