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A potential process for the formation of nanocrystals of the poorly soluble drug, ibuprofen, within a nanoporous material is demonstrated. Nanocrystalline ibuprofen (IBP) is prepared at ≤106 nm by adding a solution containing IBP to particles of controlled pore glass (CPG) within a column so that the pores contain IBP solution. The imbibed particles of CPG are then rinsed with a minimal amount of solvent to remove excess solution at the surface of CPG, and a flow of air within the column is used to evaporate the solvent, resulting in crystallization of IBP within the pores of CPG. Crystallinity is determined using X-ray powder diffraction. IBP is confirmed as being in the nanosize range by observation of a negative shift in the melting point measured by differential scanning calorimetry, and loading of IBP nanocrystals within the pores (% w/w) is determined by thermogravimetric analysis. Parameters were investigated for …