Autores
Duncan Wilson, Betty Hebecker, David L Moyes, Pedro Miramón, Nadja Jablonowski, Stephanie Wisgott, Stefanie Allert, Julian R Naglik, Bernhard Hube
Fecha de publicación
2013/10
Revista
Antimicrobial agents and chemotherapy
Volumen
57
Número
10
Páginas
5178-5180
Editor
American Society for Microbiology
Descripción
The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a “danger response” transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.
Artículos de Google Académico
D Wilson, B Hebecker, DL Moyes, P Miramón… - Antimicrobial agents and chemotherapy, 2013