Authors
Firouz M Moghaddam, Ghasem R Bardajee, Seyedeh Taimoory
Publication date
2006/2/1
Journal
Letters in Organic Chemistry
Volume
3
Issue
2
Pages
157-160
Publisher
Bentham Science Publishers
Description
KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as α,β-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.
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