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To compare the acute psychophysiological responses to blood flow restriction (BFR) exercise using a traditional research device or novel, automated system. Forty-four resistance trained individuals performed four sets of unilateral elbow flexion exercise [30% one-repetition maximum (1RM)] to volitional failure using two distinct restrictive devices [SmartCuffs PRO BFR Model (SMARTCUFF), Hokanson E20 Rapid Inflation device (HOKANSON)] and with two levels of BFR [40% limb occlusion pressure (LOP), 80% LOP]. Blood pressure (BP), muscle thickness (MT), and isometric strength (ISO) were assessed prior to and following exercise. Perceptual responses [ratings of perceived exertion (RPE), discomfort] were assessed prior to exercise and following each exercise set. Data are displayed as means (SD). Immediately following exercise with 40% LOP, there were no statistical …