Articles with public access mandates - Matthieu SchapiraLearn more
Available somewhere: 101
Combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes
SH Barghout, MK Mann, A Aman, Y Yu, MG Alteen, AD Schimmer, ...
ACS Chemical Biology 17 (10), 2801-2816, 2022
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada
ChemBioPort: an online portal to navigate the structure, function and chemical inhibition of the human proteome
L Liu, E Rovers, M Schapira
Database 2022, baac088, 2022
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–7
M Gütschow, JJ Vanden Eynde, J Jampilek, CB Kang, AA Mangoni, ...
Molecules 25 (13), 2968, 2020
Mandates: US National Institutes of Health
Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6
RJ Harding, I Franzoni, MK Mann, MM Szewczyk, B Mirabi, ...
Journal of Medicinal Chemistry 66 (15), 10273-10288, 2023
Mandates: US Department of Energy, US National Institutes of Health, Austrian Science …
HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
RJ Harding, JC Deme, JF Hevler, S Tamara, A Lemak, JP Cantle, ...
bioRxiv, 2021.04. 02.438217, 2021
Mandates: US National Institutes of Health, Genome Canada, Wellcome Trust, European …
Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors
AK Nigam, MFD Hurley, F Li, E Konkoľová, M Klíma, J Trylčová, R Pollice, ...
bioRxiv, 2023
Mandates: Swiss National Science Foundation
Target 2035–an update on private sector contributions
S Ackloo, AA Antolin, JM Bartolome, H Beck, A Bullock, UAK Betz, ...
RSC Medicinal Chemistry 14 (6), 1002-1011, 2023
Mandates: Genome Canada, European Commission, Ontario Institute for Cancer Research
A first-in-class, highly selective and cell-active allosteric inhibitor of protein arginine methyltransferase 6 (PRMT6)
Y Shen, F Li, MM Szewczyk, L Halebelian, I Chau, MS Eram, CD Seña, ...
bioRxiv, 2020.12. 04.412569, 2020
Mandates: US National Institutes of Health, Genome Canada, Wellcome Trust
Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle
MK Mann, E Wolf, M Silva, HA Kwak, B Wilson, A Bolotokova, DJ Wilson, ...
ACS omega 9 (1), 917-924, 2023
Mandates: Genome Canada
A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening
C Bedart, G Shimokura, FG West, TE Wood, RA Batey, JJ Irwin, ...
Mandates: Genome Canada
Benchmarking PROTAC docking and virtual screening tools
E Rovers, M Schapira
bioRxiv, 2023.08. 30.555318, 2023
Mandates: Genome Canada
Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)
S Perveen, CA Zepeda-Velázquez, D McLeod, R Marcellus, ...
bioRxiv, 2022.01. 05.475077, 2022
Mandates: Genome Canada
The SARS-CoV-2 replication-transcription complex is a priority target for broad-spectrum pan-coronavirus drugs
S Yazdani, N De Maio, Y Ding, V Shahani, N Goldman, M Schapira
bioRxiv, 2021.03. 23.436637, 2021
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada …
Negative controls of chemical probes can be misleading
J Lee, M Schapira
bioRxiv, 2020.09. 30.320465, 2020
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada …
A data science roadmap for open science organizations engaged in early-stage drug discovery
K Edfeldt, AM Edwards, O Engkvist, J Günther, M Hartley, DG Hulcoop, ...
Nature Communications 15 (1), 5640, 2024
Mandates: European Commission
Structure-Based Survey of the Human Proteome for Opportunities in Proximity Pharmacology
E Rovers, M Schapira
bioRxiv, 2022.01. 13.475779, 2022
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada
ProxyBind: A compendium of binding sites for proximity-induced pharmacology
E Rovers, L Liu, M Schapira
Computational and Structural Biotechnology Journal 20, 6163-6171, 2022
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada
Structure Activity Relationship of USP5 Allosteric Inhibitors
MK Mann, CA Zepeda-Velázquez, HG Alvarez, A Dong, T Kiyota, A Aman, ...
bioRxiv, 2021.05. 17.444542, 2021
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada …
The Druggable Genome as Seen from the Protein Data Bank
J Wang, S Yazdani, A Han, M Schapira
bioRxiv, 2020.02. 06.937730, 2020
Mandates: Genome Canada, Natural Sciences and Engineering Research Council of Canada …
Human SET domain bifurcated 1 (SETDB1)
P Mader, R Harding, A Dong, W Tempel, JR Walker, E Dobrovetsky, ...
Tudor domain, 2016
Mandates: Genome Canada, Wellcome Trust
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