| Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase JA Newman, A Douangamath, S Yadzani, Y Yosaatmadja, A Aimon, ... Nature Communications 12 (1), 4848, 2021 | 171 | 2021 |
| Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5 G Senisterra, H Wu, A Allali-Hassani, GA Wasney, D Barsyte-Lovejoy, ... Biochemical Journal 449 (1), 151-159, 2013 | 168 | 2013 |
| Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2 W Zheng, G Ibáñez, H Wu, G Blum, H Zeng, A Dong, F Li, T Hajian, ... Journal of the American Chemical Society 134 (43), 18004-18014, 2012 | 158 | 2012 |
| Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations H Wu, H Zeng, A Dong, F Li, H He, G Senisterra, A Seitova, S Duan, ... PloS one 8 (12), e83737, 2013 | 151 | 2013 |
| BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence L Gu, SC Frommel, CC Oakes, R Simon, K Grupp, CY Gerig, D Bär, ... Nature genetics 47 (1), 22-30, 2015 | 147 | 2015 |
| Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine M Schapira, R Abagyan, M Totrov BMC structural biology 2, 1-8, 2002 | 137 | 2002 |
| Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein MS Eram, SP Bustos, E Lima-Fernandes, A Siarheyeva, G Senisterra, ... Journal of Biological Chemistry 289 (17), 12177-12188, 2014 | 130 | 2014 |
| Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle G Min, G Zhou, M Schapira, TT Sun, XP Kong Journal of cell science 116 (20), 4087-4094, 2003 | 119 | 2003 |
| A potent, selective and cell‐active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) HÜ Kaniskan, MM Szewczyk, Z Yu, MS Eram, X Yang, K Schmidt, X Luo, ... Angewandte Chemie 127 (17), 5255-5259, 2015 | 118 | 2015 |
| A chemical biology toolbox to study protein methyltransferases and epigenetic signaling S Scheer, S Ackloo, TS Medina, M Schapira, F Li, JA Ward, AM Lewis, ... Nature communications 10 (1), 19, 2019 | 114 | 2019 |
| Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2 Y Guo, N Nady, C Qi, A Allali-Hassani, H Zhu, P Pan, MA Adams-Cioaba, ... Nucleic acids research 37 (7), 2204-2210, 2009 | 113 | 2009 |
| Suppl 1: Structural Chemistry of Human SET Domain Protein Methyltransferases M Schapira Current chemical genomics 5, 85, 2011 | 111 | 2011 |
| Discovery of a dual PRMT5–PRMT7 inhibitor D Smil, MS Eram, F Li, S Kennedy, MM Szewczyk, PJ Brown, ... ACS medicinal chemistry letters 6 (4), 408-412, 2015 | 106 | 2015 |
| TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma K Nakayama, MM Szewczyk, C dela Sena, H Wu, A Dong, H Zeng, F Li, ... Oncotarget 9 (26), 18480, 2018 | 105 | 2018 |
| An allosteric inhibitor of protein arginine methyltransferase 3 A Siarheyeva, G Senisterra, A Allali-Hassani, A Dong, E Dobrovetsky, ... Structure 20 (8), 1425-1435, 2012 | 102 | 2012 |
| Multivalent histone and DNA engagement by a PHD/BRD/PWWP triple reader cassette recruits ZMYND8 to K14ac-rich chromatin P Savitsky, T Krojer, T Fujisawa, JP Lambert, S Picaud, CY Wang, ... Cell reports 17 (10), 2724-2737, 2016 | 100 | 2016 |
| ChromoHub: a data hub for navigators of chromatin-mediated signalling L Liu, XT Zhen, E Denton, BD Marsden, M Schapira Bioinformatics 28 (16), 2205-2206, 2012 | 99 | 2012 |
| Structural biology and chemistry of protein arginine methyltransferases M Schapira, RF de Freitas Medchemcomm 5 (12), 1779-1788, 2014 | 94 | 2014 |
| Structure-based optimization of a small molecule antagonist of the interaction between WD repeat-containing protein 5 (WDR5) and mixed-lineage leukemia 1 (MLL1) M Getlik, D Smil, C Zepeda-Velazquez, Y Bolshan, G Poda, H Wu, A Dong, ... Journal of medicinal chemistry 59 (6), 2478-2496, 2016 | 91 | 2016 |
| Structural chemistry of the histone methyltransferases cofactor binding site V Campagna-Slater, MW Mok, KT Nguyen, M Feher, R Najmanovich, ... Journal of chemical information and modeling 51 (3), 612-623, 2011 | 88 | 2011 |
