Articles with public access mandates - Matthieu SchapiraLearn more
Available somewhere: 101
Epigenetic protein families: a new frontier for drug discovery
CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira
Nature reviews Drug discovery 11 (5), 384-400, 2012
Mandates: Canadian Institutes of Health Research, Genome Canada
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
Mandates: US National Institutes of Health, Cancer Research UK, UK Medical Research …
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ...
Blood, The Journal of the American Society of Hematology 117 (8), 2451-2459, 2011
Mandates: Canadian Institutes of Health Research, Genome Canada, German Research …
Targeted protein degradation: expanding the toolbox
M Schapira, MF Calabrese, AN Bullock, CM Crews
Nature reviews Drug discovery 18 (12), 949-963, 2019
Mandates: US National Institutes of Health, Genome Canada, Natural Sciences and …
A systematic analysis of atomic protein–ligand interactions in the PDB
RF de Freitas, M Schapira
Medchemcomm 8 (10), 1970-1981, 2017
Mandates: Genome Canada, Wellcome Trust
Recognition and specificity determinants of the human cbx chromodomains
L Kaustov, H Ouyang, M Amaya, A Lemak, N Nady, S Duan, GA Wasney, ...
Journal of Biological Chemistry 286 (1), 521-529, 2011
Mandates: Canadian Institutes of Health Research, Genome Canada
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
A Schuetz, J Min, A Allali-Hassani, M Schapira, M Shuen, P Loppnau, ...
Journal of Biological Chemistry 283 (17), 11355-11363, 2008
Mandates: US National Institutes of Health, Canadian Institutes of Health Research …
Structural biology of human H3K9 methyltransferases
H Wu, J Min, VV Lunin, T Antoshenko, L Dombrovski, H Zeng, ...
PloS one 5 (1), e8570, 2010
Mandates: Canadian Institutes of Health Research, Genome Canada
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ...
Nature communications 3 (1), 1288, 2012
Mandates: US National Institutes of Health, Canadian Institutes of Health Research …
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ...
Nature chemical biology 11 (8), 571-578, 2015
Mandates: Austrian Science Fund, Genome Canada, UK Medical Research Council, Wellcome …
Structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins
C Xu, K Liu, H Ahmed, P Loppnau, M Schapira, J Min
Journal of Biological Chemistry 290 (41), 24902-24913, 2015
Mandates: Genome Canada, Wellcome Trust
WD40 repeat domain proteins: a novel target class?
M Schapira, M Tyers, M Torrent, CH Arrowsmith
Nature reviews Drug discovery 16 (11), 773-786, 2017
Mandates: US National Institutes of Health, Canadian Cancer Society, Canadian …
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ...
ACS chemical biology 11 (3), 772-781, 2016
Mandates: US Department of Energy, US National Institutes of Health, Genome Canada …
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ...
Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014
Mandates: Canadian Institutes of Health Research, Genome Canada, Wellcome Trust
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
G Senisterra, H Wu, A Allali-Hassani, GA Wasney, D Barsyte-Lovejoy, ...
Biochemical Journal 449 (1), 151-159, 2013
Mandates: Canadian Institutes of Health Research, Genome Canada
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
JA Newman, A Douangamath, S Yadzani, Y Yosaatmadja, A Aimon, ...
Nature Communications 12 (1), 4848, 2021
Mandates: Genome Canada, Cancer Research UK, Wellcome Trust, European Commission
Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2
W Zheng, G Ibáñez, H Wu, G Blum, H Zeng, A Dong, F Li, T Hajian, ...
Journal of the American Chemical Society 134 (43), 18004-18014, 2012
Mandates: US National Institutes of Health, Canadian Institutes of Health Research …
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations
H Wu, H Zeng, A Dong, F Li, H He, G Senisterra, A Seitova, S Duan, ...
PloS one 8 (12), e83737, 2013
Mandates: Canadian Institutes of Health Research, Genome Canada, Wellcome Trust
BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence
L Gu, SC Frommel, CC Oakes, R Simon, K Grupp, CY Gerig, D Bär, ...
Nature genetics 47 (1), 22-30, 2015
Mandates: Swiss National Science Foundation, Wellcome Trust, Swiss Cancer Foundation
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein
MS Eram, SP Bustos, E Lima-Fernandes, A Siarheyeva, G Senisterra, ...
Journal of Biological Chemistry 289 (17), 12177-12188, 2014
Mandates: Canadian Institutes of Health Research, Genome Canada, Wellcome Trust
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