AI and immunology RN Germain, EM Van Allen, G Trynka, JS Tsang, D Grün, AL Kiemen, ... Immunity 57 (6), 1177-1181, 2024 | | 2024 |
NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome R Chen, E Lukianova, IS van der Loeff, JS Spegarova, JDP Willet, ... Science Immunology 9 (95), eade5705, 2024 | | 2024 |
Human Genetics and Genomics for Drug Target Identification and Prioritization: Open Targets’ Perspective EM McDonagh, G Trynka, M McCarthy, ER Holzinger, S Khader, N Nakic, ... Annual Review of Biomedical Data Science 7, 2024 | | 2024 |
An atlas of protein-protein associations of human tissues prioritizes candidate disease genes DS Laman Trip, M van Oostrum, D Memon, F Frommelt, D Baptista, ... bioRxiv, 2024.05. 15.594301, 2024 | | 2024 |
Arrayed screening of immune disease associated genes identifies modulators of CD4+ regulatory T cell suppression O Bakker, G Griffiths, B Soskic, K Maratou, M Bartholomew, J Smith, ... EUROPEAN JOURNAL OF HUMAN GENETICS 32, 450-450, 2024 | | 2024 |
Single cell expression, surface proteins, and T and B cell receptor usage in a multi ancestry systemic lupus erythematosus cohort N de Klein, T Rupall, B Chau, W Lee, H Jang, S Eastham, N Buang, ... EUROPEAN JOURNAL OF HUMAN GENETICS 32, 19-19, 2024 | | 2024 |
Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia SJ Washer, M Perez-Alcantara, Y Chen, J Steer, WS James, G Trynka, ... Scientific Reports 12 (1), 19454, 2022 | 19 | 2022 |
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells ME Lynall, B Soskic, J Hayhurst, J Schwartzentruber, DF Levey, ... Nature communications 13 (1), 6102, 2022 | 20 | 2022 |
Research briefing PA Sossi | | 2022 |
A molecular map of T cell activation gives insights into immune disease B Soskic, G Trynka NATURE GENETICS 54 (6), 752-753, 2022 | | 2022 |
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation B Soskic, E Cano-Gamez, DJ Smyth, K Ambridge, Z Ke, JC Matte, ... Nature genetics 54 (6), 817-826, 2022 | 71 | 2022 |
Robust temporal map of human in vitro myelopoiesis using single-cell genomics C Alsinet, MN Primo, V Lorenzi, E Bello, I Kelava, CP Jones, ... Nature communications 13 (1), 2885, 2022 | 19 | 2022 |
Immune disease variants modulate gene expression in regulatory CD4+ T cells L Bossini-Castillo, DA Glinos, N Kunowska, G Golda, AA Lamikanra, ... Cell genomics 2 (4), 2022 | 25 | 2022 |
Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cells ME Lynall, B Soskic, J Hayhurst, J Schwartzentruber, DF Levey, ... medRxiv, 2021.08. 04.21261606, 2021 | 5 | 2021 |
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney JM Eales, X Jiang, X Xu, S Saluja, A Akbarov, E Cano-Gamez, ... Nature genetics 53 (5), 630-637, 2021 | 47 | 2021 |
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney X Jiang, JM Eales, D Scannali, A Nazgiewicz, P Prestes, M Maier, ... European heart journal 41 (48), 4580-4588, 2020 | 50 | 2020 |
Functional studies of GWAS variants are gaining momentum F Lichou, G Trynka Nature communications 11 (1), 6283, 2020 | 54 | 2020 |
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation DA Glinos, B Soskic, C Williams, A Kennedy, L Jostins, DM Sansom, ... Genes & Immunity 21 (6), 390-408, 2020 | 29 | 2020 |
Perspectives on ENCODE F Abascal, R Acosta, NJ Addleman, J Adrian, V Afzal, B Aken, JA Akiyama Nature 583 (7818), 693-699, 2020 | 25 | 2020 |
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells R Nasrallah, CJ Imianowski, L Bossini-Castillo, FM Grant, M Dogan, ... Nature 583 (7816), 447-452, 2020 | 50 | 2020 |