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Claire Churchhouse
Claire Churchhouse
Senior Advisor II, Broad Institute
Verified email at broadinstitute.org
Title
Cited by
Year
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation
CE Carey, R Shafee, R Wedow, A Elliott, DS Palmer, J Compitello, ...
Nature Human Behaviour, 1-17, 2024
2024
The landscape of gene loss and missense variation across the mammalian tree informs on gene essentiality
C Liao, R Ye, F Ivankovic, J Fu, RK Walters, C Lowther, E Valkanas, ...
bioRxiv, 2024.05. 16.594531, 2024
2024
GUIDE deconstructs genetic architectures using association studies
D Lazarev, G Chau, A Bloemendal, C Churchhouse, B Neale
bioRxiv, 2024.05. 03.592285, 2024
2024
Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects
KJ Karczewski, R Gupta, M Kanai, W Lu, K Tsuo, Y Wang, RK Walters, ...
medRxiv, 2024.03. 13.24303864, 2024
72024
Polygenic risk scores from multi-ancestry GWAS of> 450 phenotypes in the Pan-UK Biobank Project offer insights into impacts of genetic architecture, ancestry, and statistical …
K Tsuo, Y Wang, K Karczewski, R Gupta, M Kanai, N Baya, R Walters, ...
EUROPEAN JOURNAL OF HUMAN GENETICS 32, 11-11, 2024
2024
A second update on mapping the human genetic architecture of COVID-19
M Kanai, SJ Andrews, M Cordioli, C Stevens, BM Neale, M Daly, A Ganna, ...
Nature 621 (7977), E7-E26, 2023
212023
Analysis of genetic dominance in the UK Biobank
DS Palmer, W Zhou, L Abbott, EM Wigdor, N Baya, C Churchhouse, ...
Science 379 (6639), 1341-1348, 2023
232023
CONTEXTUALIZING PSYCHIATRIC CONSTRUCTS AND THEIR RELATIONSHIPS TO PUBLIC HEALTH VIA BIOBANK-SCALE FACTOR ANALYSIS
C Carey, R Shafee, R Wedow, D Palmer, L Abbott, D Howrigan, ...
European Neuropsychopharmacology 63, e112-e113, 2022
2022
Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
KJ Karczewski, M Solomonson, KR Chao, JK Goodrich, G Tiao, W Lu, ...
Cell Genomics 2 (9), 2022
1122022
Principled distillation of multidimensional UK Biobank data reveals insights into the correlated human phenome
CE Carey, R Shafee, A Elliott, DS Palmer, J Compitello, M Kanai, L Abbott, ...
medRxiv, 2022.09. 02.22279546, 2022
22022
COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19
GA Pathak, R Polimanti, J Karjalainen, M Daly, A Ganna, MJ Daly, ...
University of Leicester, 2022
2022
Whole-genome sequencing reveals host factors underlying critical COVID-19
A Kousathanas, E Pairo-Castineira, K Rawlik, A Stuckey, CA Odhams, ...
Nature 607 (7917), 97-103, 2022
2402022
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
DS Palmer, DP Howrigan, SB Chapman, R Adolfsson, N Bass, ...
Nature genetics 54 (5), 541-547, 2022
892022
Rare coding variants in ten genes confer substantial risk for schizophrenia
T Singh, T Poterba, D Curtis, H Akil, M Al Eissa, JD Barchas, N Bass, ...
Nature 604 (7906), 509-516, 2022
4592022
A data harmonization pipeline to leverage external controls and boost power in GWAS
D Chen, K Tashman, DS Palmer, B Neale, K Roeder, A Bloemendal, ...
Human Molecular Genetics 31 (3), 481-489, 2022
62022
Sex-dependent shared and nonshared genetic architecture across mood and psychotic disorders
GAM Blokland, J Grove, CY Chen, C Cotsapas, S Tobet, R Handa, ...
Biological psychiatry 91 (1), 102-117, 2022
842022
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
7472021
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
M D’Antonio, JP Nguyen, TD Arthur, H Matsui, BM Neale, M Daly, ...
Cell reports 37 (7), 2021
302021
Distinct gene-set burden patterns underlie common generalized and focal epilepsies
M Koko, R Krause, T Sander, DR Bobbili, M Nothnagel, P May, H Lerche, ...
EBioMedicine 72, 2021
112021
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations
R Stevelink, JJ Luykx, BD Lin, C Leu, D Lal, AW Smith, D Schijven, ...
Epilepsia 62 (7), 1518-1527, 2021
72021
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