Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann SNAr and Reactive Crystallization Cascade LE Sirois, NA White, J Shen, DM Dalton, D Zell, F St-Jean, F Gosselin Organic Process Research & Development, 2024 | | 2024 |
Synthesis of a bis-mesylate salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl) amino)-6-methylisoquinolin-5-yl) thieno [3, 2-d] pyrimidine-7-carboxamide and intermediates thereto F Gosselin, SG Koenig, EV Mercado-marin, A Stumpf, D Zell, HM Zhang, ... US Patent 11,999,749, 2024 | 1 | 2024 |
Scalable Synthesis of 6-Chloro-1H-pyrazolo[3,4-b]pyrazine via a Continuous Flow Formylation/Hydrazine Cyclization Cascade TM Bass, D Zell, SM Kelly, TC Malig, JG Napolitano, LE Sirois, C Han, ... Organic Process Research & Development, 2024 | 1 | 2024 |
Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3H-spiro[benzofuran-2,4′-piperidine] Building Block MM Pompeo, SM Kelly, F St-Jean, TM Bass, DM Dalton, D Zell, C Han, ... The Journal of Organic Chemistry, 2024 | 1 | 2024 |
Data Science Guided Multiobjective Optimization of a Stereoconvergent Nickel-Catalyzed Reduction of Enol Tosylates to Access Trisubstituted Alkenes NP Romer, DS Min, JY Wang, RC Walroth, KA Mack, LE Sirois, F Gosselin, ... ACS Catalysis 14 (7), 4699-4708, 2024 | | 2024 |
Stereoconvergent and-divergent synthesis of tetrasubstituted alkenes by nickel-catalyzed cross-couplings D Zell, C Kingston, J Jermaks, SR Smith, N Seeger, J Wassmer, LE Sirois, ... Journal of the American Chemical Society 143 (45), 19078-19090, 2021 | 51 | 2021 |
An Efficient Second-Generation Manufacturing Process for the pan-RAF Inhibitor Belvarafenib D Zell, ME Dalziel, DE Carrera, A Stumpf, S Bachmann, E Mercado-Marin, ... Organic Process Research & Development 25 (10), 2338-2350, 2021 | 6 | 2021 |
Total synthesis of kadcoccinic acid A trimethyl ester BM Trost, G Zhang, H Gholami, D Zell Journal of the American Chemical Society 143 (31), 12286-12293, 2021 | 15 | 2021 |
Palladium-catalyzed asymmetric allylic fluoroalkylation/trifluoromethylation BM Trost, H Gholami, D Zell Journal of the American Chemical Society 141 (29), 11446-11451, 2019 | 53 | 2019 |
3d transition metals for C–H activation P Gandeepan, T Müller, D Zell, G Cera, S Warratz, L Ackermann Chemical Reviews 119 (4), 2192-2452, 2018 | 1922 | 2018 |
Enantio‐and Diastereoselective Synthesis of Chiral Allenes by Palladium‐Catalyzed Asymmetric [3+ 2] Cycloaddition Reactions BM Trost, D Zell, C Hohn, G Mata, A Maruniak Angewandte Chemie 130 (39), 13098-13102, 2018 | 65 | 2018 |
C–H/C–F functionalization by E-selective ruthenium (II) catalysis U Dhawa, D Zell, R Yin, S Okumura, M Murakami, L Ackermann Journal of Catalysis 364, 14-18, 2018 | 12 | 2018 |
Cobalt-catalyzed C–H cyanations: Insights into the reaction mechanism and the role of London dispersion E Detmar, V Müller, D Zell, L Ackermann, M Breugst Beilstein Journal of Organic Chemistry 14 (1), 1537-1545, 2018 | 23 | 2018 |
Asymmetric Iron‐Catalyzed C−H Alkylation Enabled by Remote Ligand meta‐Substitution J Loup, D Zell, JCA Oliveira, H Keil, D Stalke, L Ackermann Angewandte Chemie 129 (45), 14385-14389, 2017 | 145 | 2017 |
Mild Cobalt (III)‐Catalyzed Allylative C− F/C− H Functionalizations at Room Temperature D Zell, V Müller, U Dhawa, M Bursch, RR Presa, S Grimme, L Ackermann Chemistry–A European Journal 23 (50), 12145-12148, 2017 | 104 | 2017 |
Full selectivity control in cobalt (III)‐catalyzed C− H alkylations by switching of the C− H activation mechanism D Zell, M Bursch, V Müller, S Grimme, L Ackermann Angewandte Chemie 129 (35), 10514-10518, 2017 | 257 | 2017 |
C–F/C–H functionalization by manganese (I) catalysis: expedient (per) fluoro-allylations and alkenylations D Zell, U Dhawa, V Müller, M Bursch, S Grimme, L Ackermann Acs Catalysis 7 (6), 4209-4213, 2017 | 166 | 2017 |
Ruthenium (II)-catalyzed C–H oxygenations of reusable sulfoximine benzamides K Raghuvanshi, D Zell, L Ackermann Organic letters 19 (6), 1278-1281, 2017 | 102 | 2017 |
CH Activation by Ruthenium (II), Cobalt (III) and Manganese (I) Catalysis D Zell Niedersächsische Staats-und Universitätsbibliothek Göttingen, 2017 | 1 | 2017 |
Ruthenium (II)-catalyzed C− H methylation with trifluoroborates MDL Tonin, D Zell, V Müller, L Ackermann Synthesis 49 (01), 127-134, 2017 | 25 | 2017 |