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Pradeep J. Nathan
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Year
Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of CYB003, a Deuterated Psilocybin Analog in Patients With Major Depressive Disorder
S Krempien, A Inamdar, M Shenouda, K Johnson, SA Maass-Robinsin, ...
NEUROPSYCHOPHARMACOLOGY 48, 195-196, 2023
2023
Early Clinical Development of a Deuterated N, N-Dimethyltryptamine (DMT) Analog for the Treatment of Mental Health Conditions
A Inamdar, K van der Heijden, P Nathan, A Reichelt, A Hegle, M Otto, ...
NEUROPSYCHOPHARMACOLOGY 48, 310-311, 2023
2023
Translational Studies of AZD4041, a First In-Class Selective Orexin 1 Receptor Antagonist for the Treatment of Opioid Use Disorder
P Nathan, P Kenny, T Kamenecka, G Meno-Tetang, N Sane, S Soleman, ...
NEUROPSYCHOPHARMACOLOGY 48, 451-451, 2023
2023
Safety, pharmacokinetics and pharmacodynamics of n, n-dimethyltryptamine administered as intravenous infusion in healthy smokers
K Van Der Heijden, SM Boloni, R Zuiker, M Otto, AP Hegle, A Reichelt, ...
Neuroscience Applied 2, 103731, 2023
2023
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with …
PJ Nathan, SB Millais, A Godwood, O Dewit, DM Cross, J Liptrot, ...
Alzheimer's & Dementia: Translational Research & Clinical Interventions 8 (1 …, 2022
42022
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a …
C Bakker, T Tasker, J Liptrot, EP Hart, ES Klaassen, RJ Doll, GA Brown, ...
Alzheimer's Research & Therapy 13, 1-19, 2021
152021
From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease
AJH Brown, SJ Bradley, FH Marshall, GA Brown, KA Bennett, J Brown, ...
Cell 184 (24), 5886-5901. e22, 2021
542021
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1‐acetylcholine receptor agonist: A randomized cross‐over trial
C Bakker, S Prins, J Liptrot, EP Hart, ES Klaassen, GA Brown, A Brown, ...
British Journal of Clinical Pharmacology 87 (11), 4439-4449, 2021
12021
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
J Palacios-Filardo, M Udakis, GA Brown, BG Tehan, MS Congreve, ...
Nature communications 12 (1), 5475, 2021
322021
Spatial Covariance of Cholinergic Muscarinic M1/M4 Receptors in Parkinson's Disease
SJ Colloby, PJ Nathan, G Bakker, RA Lawson, AJ Yarnall, DJ Burn, ...
Movement Disorders 36 (8), 1879-1888, 2021
82021
First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1‐receptor partial agonist for the …
C Bakker, T Tasker, J Liptrot, EP Hart, ES Klaassen, S Prins, ...
British Journal of Clinical Pharmacology 87 (7), 2945-2955, 2021
132021
Cognitive Go/No-Go decision-making criteria in Alzheimer’s disease drug development
AM Wessels, CJ Edgar, PJ Nathan, ER Siemers, P Maruff, J Harrison
Drug Discovery Today 26 (5), 1330-1336, 2021
32021
Lessons learned from using fMRI in the early clinical development of a mu-opioid receptor antagonist for disorders of compulsive consumption
PJ Nathan, G Bakker
Psychopharmacology 238 (5), 1255-1263, 2021
62021
Safety, cand exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
C Bakker, T Tasker, J Liptrot, EP Hart, ES Klaassen, RJ Doll, GA Brown, ...
Alzheimer's Research & Therapy 13 (1), NA-NA, 2021
2021
Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
J Palacios-Filardo, M Udakis, GA Brown, BG Tehan, MS Congreve, ...
Nature Communications 12, 2021
12021
Convergent and discriminant validity of default mode network and limbic network perfusion in amnestic mild cognitive impairment patients
G Quattrini, M Marizzoni, FB Pizzini, IB Galazzo, M Aiello, M Didic, ...
Journal of Alzheimer's Disease 82 (4), 1797-1808, 2021
72021
Brain perfusion in Alzheimer’s disease networks and association with pathophysiological features in mild cognitive impairment patients.
G Quattrini, M Marizzoni, FB Pizzini, IB Galazzo, M Didic, A Soricelli, ...
AAIC Neuroscience Next, 2020
2020
Brain perfusion changes in Alzheimer's disease networks and their association with pathophysiological features in amnestic mild cognitive impairment patients.
G Quattrini, M Marizzoni, FB Pizzini, IB Galazzo, M Didic, A Soricelli, ...
EUROPEAN JOURNAL OF NEUROLOGY 27, 375-375, 2020
2020
Cholinergic muscarinic M1/M4 receptor networks in dementia with Lewy bodies
SJ Colloby, PJ Nathan, IG McKeith, G Bakker, JT O’Brien, JP Taylor
Brain Communications 2 (2), fcaa098, 2020
102020
Basal Forebrain Volumes Predict Circuit Specific Functional Sensitivity to Muscarinic M1 Receptor Modulation on Cognitive Function in Healthy Controls and Patients with …
P Nathan, G Bakker, A Godwood, C Vingerhoets, M Caan, O Bloemen, ...
NEUROPSYCHOPHARMACOLOGY 44 (SUPPL 1), 173-173, 2019
2019
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