| 5-(4, 6-Dimorpholino-1, 3, 5-triazin-2-yl)-4-(trifluoromethyl) pyridin-2-amine (PQR309), a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor as … F Beaufils, N Cmiljanovic, V Cmiljanovic, T Bohnacker, A Melone, ... Journal of medicinal chemistry 60 (17), 7524-7538, 2017 | 123 | 2017 |
| 67 DNA-protein crosslink repair: proteases as DNA repair enzymes JE Burke, RL Williams, AB Ward, IA Wilson, Z Debyser, F Christ, ... | | |
| A class of highly selective inhibitors bind to an active state of PI3Kγ G Gangadhara, G Dahl, T Bohnacker, R Rae, J Gunnarsson, S Blaho, ... Nature chemical biology 15 (4), 348-357, 2019 | 47 | 2019 |
| A Computer Method for Scanning and Analysis of Dot Blots RL WILLIAMS, D CASCIO, PA WIGHT, SR SPINDLER DNA 4 (3), 255-262, 1985 | 4 | 1985 |
| A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling ZA Knight, B Gonzalez, ME Feldman, ER Zunder, DD Goldenberg, ... Cell 125 (4), 733-747, 2006 | 1400 | 2006 |
| A role for the ESCRT system in cell division in archaea RY Samson, T Obita, SM Freund, RL Williams, SD Bell Science 322 (5908), 1710-1713, 2008 | 368 | 2008 |
| A segment of cold shock protein directs the folding of a combinatorial protein S de Bono, L Riechmann, E Girard, RL Williams, G Winter Proceedings of the National Academy of Sciences 102 (5), 1396-1401, 2005 | 47 | 2005 |
| A small-molecule PI3Kα activator for cardioprotection and neuroregeneration GQ Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, ... Nature 618 (7963), 159-168, 2023 | 30 | 2023 |
| A tale of two teachers: Integrating education for sustainability, English and mathematics for a sustainable future using ethical dilemma storypedagogy E Taylor, PC Taylor, R Williams, T Manea 7th International Conference on Science, Mathematics and Technology Education, 2012 | 1 | 2012 |
| A Ternary Metal Binding Site in the C2 Domain of Phosphoinositide-Specific Phospholipase C-δ1, LO Essen, O Perisic, DE Lynch, M Katan, RL Williams Biochemistry 36 (10), 2753-2762, 1997 | 204 | 1997 |
| Ab initio self‐consistent field and potential‐dependent partial equalization of orbital electronegativity calculations of hydration properties of N‐acetyl‐N′‐methyl‐alanineamide JA Grant, RL Williams, HA Scheraga Biopolymers: Original Research on Biomolecules 30 (9‐10), 929-949, 1990 | 52 | 1990 |
| Abstract A32: The role of the ribosome in GCN2's ability to sense amino acid deprivation and initiate the integrated stress response AJ Inglis, S Shao, GR Masson, O Perisic, RS Hegde, RL Williams Cancer Research 77 (6_Supplement), A32-A32, 2017 | | 2017 |
| Abstract IA02: G-proteins regulating PI3Ks and PI4KIIIβ regulating a G-protein JE Burke, AJ Inglis, O Vadas, O Perisic, GR Masson, SH McLaughlin, ... Molecular Cancer Therapeutics 14 (7_Supplement), IA02-IA02, 2015 | 1 | 2015 |
| Abstract IA10: Structure and dynamics of Rag heterodimers in a complex with mTORC1 M Anandapadamanaban, O Perisic, A Berndt, GR Masson, J Kaufman, ... Molecular Cancer Research 18 (10_Supplement), IA10-IA10, 2020 | | 2020 |
| Accomplishing'Just-in-Time'Production M Rouncefield, M Hartswood, R Procter, R Slack, A Voss, R Williams | | 2002 |
| Acquired lobar emphysema in premature infants with bronchopulmonary dysplasia: an iatrogenic disease? KE Miller, DK Edwards, S Hilton, D Collins, F Lynch, R Williams Radiology 138 (3), 589-592, 1981 | 57 | 1981 |
| Activation of GCN2 by the ribosomal P-stalk AJ Inglis, GR Masson, S Shao, O Perisic, SH McLaughlin, RS Hegde, ... Proceedings of the National Academy of Sciences 116 (11), 4946-4954, 2019 | 158 | 2019 |
| Activation of PI3K by Ras: Single Molecule Studies of the Activation Mechanism T Buckles, B Ziemba, JE Burke, G Masson, R Williams, JJ Falke Biophysical Journal 112 (3), 393a, 2017 | | 2017 |
| Allosteric activation of PI3Kα by oncogenic mutations JE Burke, O Perisic, RL Williams Oncotarget 4 (2), 180, 2013 | 8 | 2013 |
| An experiment regarding crystallization of soluble proteins in the presence of beta-octyl glucoside. A McPherson, S Koszelak, H Axelrod, J Day, R Williams, L Robinson, ... Journal of Biological Chemistry 261 (4), 1969-1975, 1986 | 133 | 1986 |
John E BurkeProfessor of Biochemistry and Microbiology, University of VictoriaVerified email at uvic.ca