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Philippe Nuhant
Philippe Nuhant
Senior Research Scientist at Vertex Pharmaceuticals
Verified email at vrtx.com
Title
Cited by
Year
(Diisopinocampheyl)borane-Mediated Reductive Aldol Reactions of Acrylate Esters: Enantioselective Synthesis of Anti-Aldols
C Allais, P Nuhant, WR Roush
Organic letters 15 (15), 3922-3925, 2013
222013
(Diisopinocampheyl) borane-Mediated Reductive Aldol Reactions: Highly Enantio and Diastereoselective Synthesis of Syn-Aldols from N-Acryloylmorpholine
P Nuhant, C Allais, WR Roush
Angewandte Chemie (International ed. in English) 52 (33), 2013
402013
1, 4-Reductive Aldol Reactions of Substituted α, β-Unsaturated Amides
P Knochel, D Haas
Synfacts 10 (02), 0188-0188, 2014
2014
1h-pyrazolo [4, 3-g] isoquinoline and 1h-pyrazolo [4, 3-g] quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)
S Giroux, PM Nuhant, UK Bandarage, PMG BARRANTES, Y Liao, ...
US Patent App. 17/916,405, 2023
12023
Access to Highly Substituted 7-Azaindoles from 2-Fluoropyridines via 7-Azaindoline Intermediates
P Nuhant, C Allais, MZ Chen, JW Coe, A Dermenci, OO Fadeyi, AC Flick, ...
Organic letters 17 (17), 4292-4295, 2015
202015
Access to the novel azabicyclic monomers from pyroglutaminol derivatives through diastereoselective conjugate addition followed by intramolecular cyclization
C Choi, P Nuhant, J Mousseau, C Seungwon, X Yang, B Boscoe, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016
2016
Antiproliferation activity of a small molecule repressor of liver receptor homolog 1
CA Corzo, Y Mari, MR Chang, T Khan, D Kuruvilla, P Nuhant, N Kumar, ...
Molecular pharmacology 87 (2), 296-304, 2015
472015
C–H Functionalization of heteroarenes using unactivated alkyl halides through visible-light photoredox catalysis under basic conditions
NB Bissonnette, MJ Boyd, GD May, S Giroux, P Nuhant
The Journal of Organic Chemistry 83 (18), 10933-10940, 2018
392018
Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)
N Kumar, LA Solt, J Conkright, Y Wang, MA Istrate, SA Busby, ...
Probe reports from the NIH molecular libraries program [Internet], 2011
92011
Condensed tricyclic pyrroles as alpha-1 antitrypsin modulators
UK Bandarage, CM Bligh, D Boucher, MJ BOYD, MA Brodney, MP Clark, ...
2022
Condensed tryciclic pyrroles as alpha-1 antitrypsin modulators
UK Bandarage, CM Bligh, D Boucher, MJ BOYD, MA Brodney, MP Clark, ...
2020
Development of a double allylboration reagent targeting 1, 5-syn-(E)-diols: application to the synthesis of the C (23)–C (40) fragment of tetrafibricin
P Nuhant, J Kister, R Lira, A Sorg, WR Roush
Tetrahedron 67 (35), 6497-6512, 2011
272011
Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α
C Doebelin, Y He, S Campbell, P Nuhant, N Kumar, M Koenig, ...
Medicinal Chemistry 15 (6), 676-684, 2019
22019
Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally …
ME Schnute, M Wennerstål, J Alley, M Bengtsson, JR Blinn, CW Bolten, ...
Journal of Medicinal Chemistry 61 (23), 10415-10439, 2018
322018
Electrochemically enabled chan–lam couplings of aryl boronic acids and anilines
RP Wexler, P Nuhant, TJ Senter, ZJ Gale-Day
Organic letters 21 (12), 4540-4543, 2019
512019
Enantio- and Diastereoselective Synthesis of (E)-1,5-syn-Diols: Application to the Synthesis of the C(23)−C(40) Fragment of Tetrafibricin
J Kister, P Nuhant, R Lira, A Sorg, WR Roush
Organic letters 13 (7), 1868-1871, 2011
462011
Enantio- and Diastereoselective Synthesis of N-Acetyl Dihydrotetrafibricin Methyl Ester
P Nuhant, WR Roush
Journal of the American Chemical Society 135 (14), 5340-5343, 2013
302013
Enhancement of 5-Aminopenta-2,4-dienals Electrophilicity via Activation by O,N-Bistrifluoroacetylation. Application to an N-Acyl Pictet−Spengler Reaction
P Nuhant, SB Raikar, JC Wypych, B Delpech, C Marazano
The Journal of Organic Chemistry 74 (24), 9413-9421, 2009
272009
Further insight from model experiments into a possible scenario concerning the origin of manzamine alkaloids
JC Wypych, TM Nguyen, P Nuhant, M Bénéchie, C Marazano
Angewandte Chemie International Edition 47 (29), 5418-5421, 2008
472008
Generation of stereochemically defined tetrasubstituted enolborinates by 1, 4-hydroboration of α, β-unsaturated morpholine carboxamides with (diisopinocampheyl) borane.
C Allais, AS Tsai, P Nuhant, WR Roush
Angewandte Chemie International Edition 52 (49), 2013
582013
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