| Endothelial TLR4 and the microbiome drive cerebral cavernous malformations AT Tang, JP Choi, JJ Kotzin, Y Yang, CC Hong, N Hobson, R Girard, ... Nature 545 (7654), 305-310, 2017 | 296 | 2017 |
| Cerebral hemorrhage: pathophysiology, treatment, and future directions J Magid-Bernstein, R Girard, S Polster, A Srinath, S Romanos, IA Awad, ... Circulation research 130 (8), 1204-1229, 2022 | 237 | 2022 |
| PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism AA Ren, DA Snellings, YS Su, CC Hong, M Castro, AT Tang, MR Detter, ... Nature 594 (7862), 271-276, 2021 | 134 | 2021 |
| Surgical performance determines functional outcome benefit in the minimally invasive surgery plus recombinant tissue plasminogen activator for intracerebral hemorrhage … IA Awad, SP Polster, J Carrión-Penagos, RE Thompson, Y Cao, A Stadnik, ... Neurosurgery 84 (6), 1157-1168, 2019 | 126 | 2019 |
| Cerebral cavernous malformation: from mechanism to therapy DA Snellings, CC Hong, AA Ren, MA Lopez-Ramirez, R Girard, A Srinath, ... Circulation research 129 (1), 195-215, 2021 | 111 | 2021 |
| Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations MA Lopez-Ramirez, G Fonseca, HA Zeineddine, R Girard, T Moore, ... Journal of Experimental Medicine 214 (11), 3331-3346, 2017 | 96 | 2017 |
| RhoA kinase inhibition with fasudil versus simvastatin in murine models of cerebral cavernous malformations R Shenkar, C Shi, C Austin, T Moore, R Lightle, Y Cao, L Zhang, M Wu, ... Stroke 48 (1), 187-194, 2017 | 94 | 2017 |
| Atorvastatin treatment of cavernous angiomas with symptomatic hemorrhage exploratory proof of concept (AT CASH EPOC) trial SP Polster, A Stadnik, AL Akers, Y Cao, GA Christoforidis, MD Fam, ... Neurosurgery 85 (6), 843-853, 2019 | 72 | 2019 |
| Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice MA Lopez-Ramirez, A Pham, R Girard, T Wyseure, P Hale, A Yamashita, ... Blood, The Journal of the American Society of Hematology 133 (3), 193-204, 2019 | 72 | 2019 |
| Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation AT Tang, KR Sullivan, CC Hong, LM Goddard, A Mahadevan, A Ren, ... Science translational medicine 11 (520), eaaw3521, 2019 | 66 | 2019 |
| Vascular permeability in cerebral cavernous malformations AG Mikati, O Khanna, L Zhang, R Girard, R Shenkar, X Guo, A Shah, ... Journal of Cerebral Blood Flow & Metabolism 35 (10), 1632-1639, 2015 | 64 | 2015 |
| Surgical performance in minimally invasive surgery plus recombinant tissue plasminogen activator for intracerebral hemorrhage evacuation phase III clinical trial MD Fam, D Hanley, A Stadnik, HA Zeineddine, R Girard, M Jesselson, ... Neurosurgery 81 (5), 860-866, 2017 | 62 | 2017 |
| Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity R Girard, E Météreau, J Thomas, M Pugeat, C Qu, JC Dreher Scientific reports 7 (1), 44917, 2017 | 61 | 2017 |
| Plasma biomarkers of inflammation and angiogenesis predict cerebral cavernous malformation symptomatic hemorrhage or lesional growth R Girard, HA Zeineddine, J Koskimäki, MD Fam, Y Cao, C Shi, T Moore, ... Circulation research 122 (12), 1716-1721, 2018 | 58 | 2018 |
| Plasma biomarkers of inflammation reflect seizures and hemorrhagic activity of cerebral cavernous malformations R Girard, HA Zeineddine, MD Fam, A Mayampurath, Y Cao, C Shi, ... Translational stroke research 9, 34-43, 2018 | 50 | 2018 |
| Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations R Girard, MD Fam, HA Zeineddine, H Tan, AG Mikati, C Shi, M Jesselson, ... Journal of neurosurgery 127 (1), 102-110, 2016 | 50 | 2016 |
| Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease R Shenkar, A Peiper, H Pardo, T Moore, R Lightle, R Girard, N Hobson, ... Stroke 50 (3), 738-744, 2019 | 49 | 2019 |
| Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes J Koskimäki, R Girard, Y Li, L Saadat, HA Zeineddine, R Lightle, T Moore, ... JCI insight 4 (3), 2019 | 49 | 2019 |
| B-cell depletion reduces the maturation of cerebral cavernous malformations in murine models C Shi, R Shenkar, HA Zeineddine, R Girard, MD Fam, C Austin, T Moore, ... Journal of Neuroimmune Pharmacology 11, 369-377, 2016 | 46 | 2016 |
| Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation MA Lopez-Ramirez, CC Lai, SI Soliman, P Hale, A Pham, EJ Estrada, ... The Journal of clinical investigation 131 (13), 2021 | 43 | 2021 |
Issam AwadThe John Harper Seeley Professor of Neurological Surgery , University of ChicagoVerified email at uchicago.edu