Jaks and STATs: biological implications WJ Leonard, JJ O'Shea Annual review of immunology 16 (1), 293-322, 1998 | 2358 | 1998 |
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation A Laurence, CM Tato, TS Davidson, Y Kanno, Z Chen, Z Yao, RB Blank, ... Immunity 26 (3), 371-381, 2007 | 1933 | 2007 |
Generation of pathogenic TH17 cells in the absence of TGF-β signalling K Ghoreschi, A Laurence, XP Yang, CM Tato, MJ McGeachy, JE Konkel, ... Nature 467 (7318), 967-971, 2010 | 1740 | 2010 |
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells JJ O’Shea, WE Paul Science 327 (5969), 1098-1102, 2010 | 1721 | 2010 |
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes MF McDermott, I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, ... Cell 97 (1), 133-144, 1999 | 1664 | 1999 |
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway JJ O'Shea, M Gadina, RD Schreiber Cell 109 (2), S121-S131, 2002 | 1498 | 2002 |
The JAK-STAT pathway: impact on human disease and therapeutic intervention JJ O'Shea, DM Schwartz, AV Villarino, M Gadina, IB McInnes, A Laurence Annual review of medicine 66 (1), 311-328, 2015 | 1492 | 2015 |
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome JD Milner, JM Brenchley, A Laurence, AF Freeman, BJ Hill, KM Elias, ... Nature 452 (7188), 773-776, 2008 | 1346 | 2008 |
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo MJ McGeachy, Y Chen, CM Tato, A Laurence, B Joyce-Shaikh, ... Nature immunology 10 (3), 314-324, 2009 | 1323 | 2009 |
Janus kinases in immune cell signaling K Ghoreschi, A Laurence, JJ O’Shea Immunological reviews 228 (1), 273-287, 2009 | 1316 | 2009 |
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells G Wei, L Wei, J Zhu, C Zang, J Hu-Li, Z Yao, K Cui, Y Kanno, TY Roh, ... Immunity 30 (1), 155-167, 2009 | 1311 | 2009 |
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases DM Schwartz, Y Kanno, A Villarino, M Ward, M Gadina, JJ O'Shea Nature reviews Drug discovery 16 (12), 843-862, 2017 | 1247 | 2017 |
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system JS Stumhofer, A Laurence, EH Wilson, E Huang, CM Tato, LM Johnson, ... Nature immunology 7 (9), 937-945, 2006 | 1191 | 2006 |
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease JJ O'Shea, R Plenge Immunity 36 (4), 542-550, 2012 | 1155 | 2012 |
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells AA Lighvani, DM Frucht, D Jankovic, H Yamane, J Aliberti, BD Hissong, ... Proceedings of the National Academy of Sciences 98 (26), 15137-15142, 2001 | 1111 | 2001 |
Mechanisms and consequences of Jak–STAT signaling in the immune system AV Villarino, Y Kanno, JJ O'Shea Nature immunology 18 (4), 374-384, 2017 | 1069 | 2017 |
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 JS Stumhofer, JS Silver, A Laurence, PM Porrett, TH Harris, LA Turka, ... Nature immunology 8 (12), 1363-1371, 2007 | 996 | 2007 |
Cytokine signaling modules in inflammatory responses JJ O'Shea, PJ Murray Immunity 28 (4), 477-487, 2008 | 944 | 2008 |
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development SM Russell, N Tayebi, H Nakajima, MC Riedy, JL Roberts, MJ Aman, ... Science 270 (5237), 797-800, 1995 | 938 | 1995 |
JAKs and STATs in immunity, immunodeficiency, and cancer JJ O'Shea, SM Holland, LM Staudt New England Journal of Medicine 368 (2), 161-170, 2013 | 919 | 2013 |