TRPC1, a human homolog of a Drosophila store-operated channel. PD Wes, J Chevesich, A Jeromin, C Rosenberg, G Stetten, C Montell Proceedings of the National Academy of Sciences 92 (21), 9652-9656, 1995 | 823 | 1995 |
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes TF Galatro, IR Holtman, AM Lerario, ID Vainchtein, N Brouwer, PR Sola, ... Nature neuroscience 20 (8), 1162-1171, 2017 | 694 | 2017 |
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis IR Holtman, DD Raj, JA Miller, W Schaafsma, Z Yin, N Brouwer, PD Wes, ... Acta neuropathologica communications 3, 1-18, 2015 | 597 | 2015 |
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer’s disease model M Kitazawa, D Cheng, MR Tsukamoto, MA Koike, PD Wes, V Vasilevko, ... The Journal of Immunology 187 (12), 6539-6549, 2011 | 497 | 2011 |
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease AJ Whitworth, DA Theodore, JC Greene, H Beneš, PD Wes, LJ Pallanck Proceedings of the National Academy of Sciences 102 (22), 8024-8029, 2005 | 476 | 2005 |
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson’s disease M Meulener, AJ Whitworth, CE Armstrong-Gold, P Rizzu, P Heutink, ... Current Biology 15 (17), 1572-1577, 2005 | 420 | 2005 |
C. elegans odour discrimination requires asymmetric diversity in olfactory neurons PD Wes, CI Bargmann Nature 410 (6829), 698-701, 2001 | 290 | 2001 |
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease SH Cho, B Sun, Y Zhou, TM Kauppinen, B Halabisky, P Wes, ... Journal of Biological Chemistry 286 (37), 32713-32722, 2011 | 289 | 2011 |
Targeting microglia for the treatment of Alzheimer's Disease PD Wes, FA Sayed, F Bard, L Gan Glia 64 (10), 1710-1732, 2016 | 194 | 2016 |
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease K Trinh, K Moore, PD Wes, PJ Muchowski, J Dey, L Andrews, LJ Pallanck Journal of Neuroscience 28 (2), 465-472, 2008 | 178 | 2008 |
Critical data‐based re‐evaluation of minocycline as a putative specific microglia inhibitor T Möller, F Bard, A Bhattacharya, K Biber, B Campbell, E Dale, C Eder, ... Glia 64 (10), 1788-1794, 2016 | 172 | 2016 |
Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease PD Wes, IR Holtman, EWGM Boddeke, T Möller, BJL Eggen Glia 64 (2), 197-213, 2016 | 160 | 2016 |
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models S Sankaranarayanan, DM Barten, L Vana, N Devidze, L Yang, ... PloS one 10 (5), e0125614, 2015 | 156 | 2015 |
Drosophila models pioneer a new approach to drug discovery for Parkinson's disease AJ Whitworth, PD Wes, LJ Pallanck Drug discovery today 11 (3-4), 119-126, 2006 | 154 | 2006 |
Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD PD Wes, XZS Xu, HS Li, F Chien, SK Doberstein, C Montell Nature neuroscience 2 (5), 447-453, 1999 | 148 | 1999 |
Retinal targets for calmodulin include proteins implicated in synaptic transmission XZS Xu, PD Wes, H Chen, HS Li, M Yu, S Morgan, Y Liu, C Montell Journal of Biological Chemistry 273 (47), 31297-31307, 1998 | 122 | 1998 |
Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer’s disease PD Wes, A Easton, J Corradi, DM Barten, N Devidze, LB DeCarr, ... PloS one 9 (8), e106050, 2014 | 115 | 2014 |
Transient receptor potential protein subunit assembly and membrane distribution in human platelets SL Brownlow, SO Sage Thrombosis and haemostasis 94 (10), 839-845, 2005 | 112 | 2005 |
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers DM Barten, GW Cadelina, N Hoque, LB DeCarr, VL Guss, L Yang, ... Journal of Alzheimer's Disease 24 (s2), 127-141, 2011 | 108 | 2011 |
RIC, a calmodulin‐binding Ras‐like GTPase. PD Wes, M Yu, C Montell The EMBO journal 15 (21), 5839-5848, 1996 | 104 | 1996 |