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Design, synthesis and selection of DNA-encoded small-molecule libraries MA Clark, RA Acharya, CC Arico-Muendel, SL Belyanskaya, ... Nature chemical biology 5 (9), 647-654, 2009 | 640 | 2009 |
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT) H Deng, H O’Keefe, CP Davie, KE Lind, RA Acharya, GJ Franklin, J Larkin, ... Journal of medicinal chemistry 55 (16), 7061-7079, 2012 | 154 | 2012 |
Cell-based selection expands the utility of DNA-encoded small-molecule library technology to cell surface drug targets: identification of novel antagonists of the NK3 … Z Wu, TL Graybill, X Zeng, M Platchek, J Zhang, VQ Bodmer, DD Wisnoski, ... ACS Combinatorial Science 17 (12), 722-731, 2015 | 119 | 2015 |
Discovery, SAR, and X-ray binding mode study of BCATm inhibitors from a novel DNA-encoded library H Deng, J Zhou, FS Sundersingh, J Summerfield, D Somers, JA Messer, ... ACS Medicinal Chemistry Letters 6 (8), 919-924, 2015 | 75 | 2015 |
On-DNA Pd and Cu promoted C–N cross-coupling reactions X Lu, SE Roberts, GJ Franklin, CP Davie MedChemComm 8 (8), 1614-1617, 2017 | 73 | 2017 |
Discovery of a potent class of PI3Kα inhibitors with unique binding mode via encoded library technology (ELT) H Yang, PF Medeiros, K Raha, P Elkins, KE Lind, R Lehr, ND Adams, ... ACS medicinal chemistry letters 6 (5), 531-536, 2015 | 72 | 2015 |
Design and synthesis of biaryl DNA-encoded libraries Y Ding, GJ Franklin, JL DeLorey, PA Centrella, S Mataruse, MA Clark, ... ACS Combinatorial Science 18 (10), 625-629, 2016 | 59 | 2016 |
Methods for identifying compounds of interest using encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent 7,989,395, 2011 | 55 | 2011 |
Methods for synthesis of encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent 7,972,994, 2011 | 45 | 2011 |
Methods for synthesis of encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent 7,972,992, 2011 | 36 | 2011 |
Synthesis of multifunctional 2-aminobenzimidazoles on DNA via iodine-promoted cyclization L Su, J Feng, T Peng, J Wan, J Fan, J Li, J O’Connell, DR Lancia Jr, ... Organic letters 22 (4), 1290-1294, 2020 | 34 | 2020 |
DNA-encoded library hit confirmation: bridging the gap between on-DNA and off-DNA chemistry B Xia, GJ Franklin, X Lu, KL Bedard, LSC Grady, JD Summerfield, EX Shi, ... ACS Medicinal Chemistry Letters 12 (7), 1166-1172, 2021 | 21 | 2021 |
Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT) Y Ding, S Belyanskaya, JL DeLorey, JA Messer, GJ Franklin, PA Centrella, ... Bioorganic & Medicinal Chemistry 41, 116216, 2021 | 20 | 2021 |
Methods for synthesis of encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent 7,935,658, 2011 | 15 | 2011 |
Methods for synthesis of encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent 8,598,089, 2013 | 14 | 2013 |
The impact of variable selection coverage on detection of ligands from a DNA-encoded library screen KA McCarthy, GJ Franklin, DR Lancia Jr, M Olbrot, E Pardo, JC O’Connell, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (5), 515-522, 2020 | 13 | 2020 |
Methods for synthesis of encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent App. 13/023,599, 2011 | 9 | 2011 |
Methods for synthesis of encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent 8,410,028, 2013 | 6 | 2013 |
Methods for identifying compounds of interest using encoded libraries B Morgan, S Hale, CC Arico-Muendel, M Clark, R Wagner, DI Israel, ... US Patent App. 13/051,350, 2012 | 6 | 2012 |