Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies ARD Delbridge, S Grabow, A Strasser, DL Vaux Nature Reviews Cancer 16 (2), 99-109, 2016 | 836 | 2016 |
The BCL-2 protein family, BH3-mimetics and cancer therapy ARD Delbridge, A Strasser Cell Death & Differentiation 22 (7), 1071-1080, 2015 | 582 | 2015 |
Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK FFS Ke, HK Vanyai, AD Cowan, ARD Delbridge, L Whitehead, S Grabow, ... Cell 173 (5), 1217-1230. e17, 2018 | 196 | 2018 |
Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death EM Michalak, CJ Vandenberg, ARD Delbridge, L Wu, CL Scott, JM Adams, ... Genes & development 24 (15), 1608-1613, 2010 | 144 | 2010 |
The role of the apoptotic machinery in tumor suppression ARD Delbridge, LJ Valente, A Strasser Cold Spring Harbor perspectives in biology 4 (11), a008789, 2012 | 132 | 2012 |
Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice PN Kelly, S Grabow, ARD Delbridge, A Strasser, JM Adams Blood, The Journal of the American Society of Hematology 118 (24), 6380-6386, 2011 | 56 | 2011 |
Loss of p53 causes stochastic aberrant X-chromosome inactivation and female-specific neural tube defects ARD Delbridge, AJ Kueh, F Ke, NM Zamudio, F El-Saafin, N Jansz, ... Cell reports 27 (2), 442-454. e5, 2019 | 54 | 2019 |
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice S Grabow, ARD Delbridge, LJ Valente, A Strasser Blood, The Journal of the American Society of Hematology 124 (26), 3939-3946, 2014 | 48 | 2014 |
Organotypic brain slice culture microglia exhibit molecular similarity to acutely-isolated adult microglia and provide a platform to study neuroinflammation ARD Delbridge, D Huh, M Brickelmaier, JC Burns, C Roberts, R Challa, ... Frontiers in Cellular Neuroscience 14, 592005, 2020 | 47 | 2020 |
Loss of a single Mcl-1 allele inhibits MYC-driven lymphomagenesis by sensitizing pro-B cells to apoptosis S Grabow, ARD Delbridge, BJ Aubrey, CJ Vandenberg, A Strasser Cell reports 14 (10), 2337-2347, 2016 | 47 | 2016 |
Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress ARD Delbridge, JT Opferman, S Grabow, A Strasser Blood, The Journal of the American Society of Hematology 125 (21), 3273-3280, 2015 | 42 | 2015 |
Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis ARD Delbridge, S Grabow, P Bouillet, JM Adams, A Strasser Oncogene 34 (14), 1872-1876, 2015 | 26 | 2015 |
The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL ARD Delbridge, BJ Aubrey, C Hyland, JP Bernardini, L Di Rago, ... Cell death & disease 8 (7), e2914-e2914, 2017 | 25 | 2017 |
Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis S Grabow, GL Kelly, ARD Delbridge, PN Kelly, P Bouillet, JM Adams, ... Cell Death & Disease 7 (3), e2132-e2132, 2016 | 23 | 2016 |
Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice PN Kelly, S Grabow, ARD Delbridge, JM Adams, A Strasser Cell Death & Differentiation 20 (1), 57-63, 2013 | 19 | 2013 |
RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice ARD Delbridge, SHM Pang, CJ Vandenberg, S Grabow, BJ Aubrey, L Tai, ... Journal of Experimental Medicine 213 (10), 2039-2048, 2016 | 17 | 2016 |
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage K Brinkmann, P Waring, SP Glaser, V Wimmer, DL Cottle, MS Tham, ... The EMBO journal 39 (24), e105561, 2020 | 8 | 2020 |
Loss of PUMA (BBC 3) does not prevent thrombocytopenia caused by the loss of BCL‐XL (BCL 2L1) ARD Delbridge, S Chappaz, ME Ritchie, BT Kile, A Strasser, S Grabow British Journal of Haematology 174 (6), 962-969, 2016 | 8 | 2016 |
Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development ARD Delbridge, S Grabow, A Strasser Cell Death & Differentiation 24 (11), 1987-1988, 2017 | 5 | 2017 |
BCL-XL is essential for the protection from secondary anemia caused by radiation-induced fatal kidney damage K Brinkmann, P Waring, S Glaser, V Wimmer, D Nhu, L Whitehead, ... bioRxiv, 2020.04. 28.055665, 2020 | | 2020 |