Articles with public access mandates - Thomas KukarLearn more
Not available anywhere: 2
Inhibitors of Rho‐kinase modulate amyloid‐β (Aβ) secretion but lack selectivity for Aβ42
S Leuchtenberger, MP Kummer, T Kukar, E Czirr, N Teusch, SA Sagi, ...
Journal of neurochemistry 96 (2), 355-365, 2006
Mandates: German Research Foundation
Defects in RNA metabolism links FTD and ALS pathogenesis: TDP-43, FUS, and C9orf72
Q Deng, T Chalermpalanupap, T Kukar
Current Enzyme Inhibition 9 (1), 28-40, 2013
Mandates: US National Institutes of Health
Available somewhere: 28
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Mandates: Swiss National Science Foundation, US National Institutes of Health, US …
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
CC Chou, YI Zhang, ME Umoh, SW Vaughan, I Lorenzini, F Liu, ...
Nature neuroscience 21 (2), 228-239, 2018
Mandates: US National Institutes of Health, Alzheimers's UK
Substrate-targeting γ-secretase modulators
TL Kukar, TB Ladd, MA Bann, PC Fraering, R Narlawar, GM Maharvi, ...
Nature 453 (7197), 925-929, 2008
Mandates: Swiss National Science Foundation, US National Institutes of Health
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage
Q Deng, CJ Holler, G Taylor, KF Hudson, W Watkins, M Gearing, D Ito, ...
Journal of Neuroscience 34 (23), 7802-7813, 2014
Mandates: US National Institutes of Health
Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
J Root, P Merino, A Nuckols, M Johnson, T Kukar
Neurobiology of disease 154, 105360, 2021
Mandates: US National Institutes of Health
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains
BD Moore, P Chakrabarty, Y Levites, TL Kukar, AM Baine, T Moroni, ...
Alzheimer's research & therapy 4, 1-15, 2012
Mandates: US National Institutes of Health
Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN mutations
CJ Holler, G Taylor, Q Deng, T Kukar
Eneuro 4 (4), 2017
Mandates: US National Institutes of Health
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells
X Chen, J Chang, Q Deng, J Xu, TA Nguyen, LH Martens, B Cenik, ...
Journal of neuroscience 33 (21), 9202-9213, 2013
Mandates: US National Institutes of Health
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
CJ Holler, G Taylor, ZT McEachin, Q Deng, WJ Watkins, K Hudson, ...
Molecular neurodegeneration 11, 1-17, 2016
Mandates: US National Institutes of Health
Independent generation of Aβ42 and Aβ38 peptide species by γ-secretase
E Czirr, BA Cottrell, S Leuchtenberger, T Kukar, TB Ladd, H Esselmann, ...
Journal of Biological Chemistry 283 (25), 17049-17054, 2008
Mandates: German Research Foundation
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
C Verbeeck, Q Deng, M DeJesus-Hernandez, G Taylor, C Ceballos-Diaz, ...
Molecular neurodegeneration 7, 1-13, 2012
Mandates: US National Institutes of Health
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis …
TL Kukar, TB Ladd, P Robertson, SA Pintchovski, B Moore, MA Bann, ...
Journal of Biological Chemistry 286 (46), 39804-39812, 2011
Mandates: US National Institutes of Health
Short Aβ peptides attenuate Aβ42 toxicity in vivo
BD Moore, J Martin, L De Mena, J Sanchez, PE Cruz, C Ceballos-Diaz, ...
Journal of Experimental Medicine 215 (1), 283-301, 2018
Mandates: US National Institutes of Health, Howard Hughes Medical Institute
Molecular signatures of neuroinflammation induced by αsynuclein aggregates in microglial cells
S Sarkar, EB Dammer, E Malovic, AL Olsen, SA Raza, T Gao, H Xiao, ...
Frontiers in immunology 11, 33, 2020
Mandates: US National Institutes of Health
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations
M Huang, E Modeste, E Dammer, P Merino, G Taylor, DM Duong, Q Deng, ...
Acta neuropathologica communications 8, 1-25, 2020
Mandates: US National Institutes of Health
Chimeric peptide species contribute to divergent dipeptide repeat pathology in c9ALS/FTD and SCA36
ZT McEachin, TF Gendron, N Raj, M García-Murias, A Banerjee, ...
Neuron 107 (2), 292-305. e6, 2020
Mandates: US National Institutes of Health, Government of Spain
Steroids as γ-secretase modulators
JI Jung, TB Ladd, T Kukar, AR Price, BD Moore, EH Koo, TE Golde, ...
The FASEB Journal 27 (9), 3775, 2013
Mandates: US National Institutes of Health
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein
SA Sagi, CB Lessard, KD Winden, H Maruyama, JC Koo, S Weggen, ...
Journal of Biological Chemistry 286 (46), 39794-39803, 2011
Mandates: US National Institutes of Health
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