Articles with public access mandates - Muthiah ManoharanLearn more
Not available anywhere: 2
Branched multifunctional polyether polyketals: variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells
RA Shenoi, JK Narayanannair, JL Hamilton, BFL Lai, S Horte, ...
Journal of the American Chemical Society 134 (36), 14945-14957, 2012
Mandates: Canadian Institutes of Health Research
Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes
P Bhingardeve, BR Madhanagopal, H Naick, P Jain, M Manoharan, ...
The Journal of Organic Chemistry 85 (14), 8812-8824, 2020
Mandates: Department of Science & Technology, India
Available somewhere: 47
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
A Akinc, A Zumbuehl, M Goldberg, ES Leshchiner, V Busini, N Hossain, ...
Nature biotechnology 26 (5), 561-569, 2008
Mandates: Swiss National Science Foundation, US National Institutes of Health
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
H Lee, AKR Lytton-Jean, Y Chen, KT Love, AI Park, ED Karagiannis, ...
Nature nanotechnology 7 (6), 389-393, 2012
Mandates: US National Institutes of Health
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ...
Angewandte Chemie 124 (34), 8657-8661, 2012
Mandates: Canadian Institutes of Health Research
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
M Frank-Kamenetsky, A Grefhorst, NN Anderson, TS Racie, B Bramlage, ...
Proceedings of the National Academy of Sciences 105 (33), 11915-11920, 2008
Mandates: US National Institutes of Health
Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
A Wittrup, A Ai, X Liu, P Hamar, R Trifonova, K Charisse, M Manoharan, ...
Nature biotechnology 33 (8), 870-876, 2015
Mandates: US National Institutes of Health, Swedish Research Council
Development of lipidoid–siRNA formulations for systemic delivery to the liver
A Akinc, M Goldberg, J Qin, JR Dorkin, C Gamba-Vitalo, M Maier, ...
Molecular Therapy 17 (5), 872-879, 2009
Mandates: US National Institutes of Health
Influenza A virus-generated small RNAs regulate the switch from transcription to replication
JT Perez, A Varble, R Sachidanandam, I Zlatev, M Manoharan, ...
Proceedings of the National Academy of Sciences 107 (25), 11525-11530, 2010
Mandates: US National Institutes of Health
Promoter RNA links transcriptional regulation of inflammatory pathway genes
M Matsui, Y Chu, H Zhang, KT Gagnon, S Shaikh, S Kuchimanchi, ...
Nucleic acids research 41 (22), 10086-10109, 2013
Mandates: US National Institutes of Health
Unique gene‐silencing and structural properties of 2′‐fluoro‐modified siRNAs
M Manoharan, A Akinc, RK Pandey, J Qin, P Hadwiger, M John, K Mills, ...
Angewandte Chemie 123 (10), 2332-2336, 2011
Mandates: US National Institutes of Health
Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA
PS Pallan, EM Greene, PA Jicman, RK Pandey, M Manoharan, E Rozners, ...
Nucleic acids research 39 (8), 3482-3495, 2011
Mandates: US National Institutes of Health
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ...
Nucleic acids research 48 (21), 11827-11844, 2020
Mandates: US National Institutes of Health
Lipid nanoparticle delivery of siRNA to silence neuronal gene expression in the brain
RL Rungta, HB Choi, PJC Lin, RWY Ko, D Ashby, J Nair, M Manoharan, ...
Molecular therapy. Nucleic acids 2 (12), e136, 2013
Mandates: Canadian Institutes of Health Research
Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA
MR Alam, X Ming, M Fisher, JG Lackey, KG Rajeev, M Manoharan, ...
Bioconjugate chemistry 22 (8), 1673-1681, 2011
Mandates: US National Institutes of Health
Crystal structure of Middle East respiratory syndrome coronavirus helicase
W Hao, JA Wojdyla, R Zhao, R Han, R Das, I Zlatev, M Manoharan, ...
PLoS pathogens 13 (6), e1006474, 2017
Mandates: Chinese Academy of Sciences, National Natural Science Foundation of China
Systemic RNAi-mediated gene silencing in nonhuman primate and rodent myeloid cells
TI Novobrantseva, A Borodovsky, J Wong, B Klebanov, M Zafari, K Yucius, ...
Molecular Therapy-Nucleic Acids 1, 2012
Mandates: US National Institutes of Health
Preclinical development of a subcutaneous ALAS1 RNAi therapeutic for treatment of hepatic porphyrias using circulating RNA quantification
A Chan, A Liebow, M Yasuda, L Gan, T Racie, M Maier, S Kuchimanchi, ...
Molecular Therapy-Nucleic Acids 4, 2015
Mandates: US National Institutes of Health
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene
Y Wu, F Navarro, A Lal, E Basar, RK Pandey, M Manoharan, Y Feng, ...
Cell host & microbe 5 (1), 84-94, 2009
Mandates: US National Institutes of Health
Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter
M Matsui, F Sakurai, S Elbashir, DJ Foster, M Manoharan, DR Corey
Chemistry & biology 17 (12), 1344-1355, 2010
Mandates: US National Institutes of Health
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