Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma A Jusakul, I Cutcutache, CH Yong, JQ Lim, MN Huang, N Padmanabhan, ... Cancer discovery 7 (10), 1116-1135, 2017 | 772 | 2017 |
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers W Chan-On, ML Nairismägi, CK Ong, WK Lim, S Dima, C Pairojkul, ... Nature genetics 45 (12), 1474-1478, 2013 | 502 | 2013 |
Genome-wide mutational signatures of aristolochic acid and its application as a screening tool SL Poon, ST Pang, JR McPherson, W Yu, KK Huang, P Guan, WH Weng, ... Science translational medicine 5 (197), 197ra101-197ra101, 2013 | 320 | 2013 |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen MP Menden, D Wang, MJ Mason, B Szalai, KC Bulusu, Y Guan, T Yu, ... Nature communications 10 (1), 2674, 2019 | 297 | 2019 |
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma WK Lim, CK Ong, J Tan, AA Thike, CCY Ng, V Rajasegaran, SS Myint, ... Nature genetics 46 (8), 877-880, 2014 | 218 | 2014 |
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2 LD Ler, S Ghosh, X Chai, AA Thike, HL Heng, EY Siew, S Dey, LK Koh, ... Science translational medicine 9 (378), eaai8312, 2017 | 215 | 2017 |
Genomic landscapes of breast fibroepithelial tumors J Tan, CK Ong, WK Lim, CCY Ng, AA Thike, LM Ng, V Rajasegaran, ... Nature genetics 47 (11), 1341-1345, 2015 | 204 | 2015 |
The DNA structure-specific endonuclease MUS81 mediates DNA sensor STING-dependent host rejection of prostate cancer cells SSW Ho, WYL Zhang, NYJ Tan, M Khatoo, MA Suter, S Tripathi, ... Immunity 44 (5), 1177-1189, 2016 | 201 | 2016 |
The draft genome of tropical fruit durian (Durio zibethinus) BT Teh, K Lim, CH Yong, CCY Ng, SR Rao, V Rajasegaran, WK Lim, ... Nature genetics 49 (11), 1633-1641, 2017 | 180 | 2017 |
Large-scale whole-genome sequencing of three diverse Asian populations in Singapore D Wu, J Dou, X Chai, C Bellis, A Wilm, CC Shih, WWJ Soon, N Bertin, ... Cell 179 (3), 736-749. e15, 2019 | 154 | 2019 |
JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma ML Nairismägi, J Tan, JQ Lim, S Nagarajan, CCY Ng, V Rajasegaran, ... Leukemia 30 (6), 1311-1319, 2016 | 149 | 2016 |
Prediction of human population responses to toxic compounds by a collaborative competition F Eduati, LM Mangravite, T Wang, H Tang, JC Bare, R Huang, T Norman, ... Nature biotechnology 33 (9), 933-940, 2015 | 120 | 2015 |
Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. E Diffner, D Beck, E Gudgin, JA Thoms, K Knezevic, C Pridans, S Foster, ... Blood, 2013 | 91 | 2013 |
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance AL Vettore, K Ramnarayanan, G Poore, K Lim, CK Ong, KK Huang, ... Genome medicine 7, 1-15, 2015 | 88 | 2015 |
Association of NOTCH2NLC repeat expansions with Parkinson disease D Ma, YJ Tan, ASL Ng, HL Ong, W Sim, WK Lim, JX Teo, EYL Ng, EC Lim, ... JAMA neurology 77 (12), 1559-1563, 2020 | 81 | 2020 |
MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases CCY Ng, J Tan, CK Ong, WK Lim, V Rajasegaran, NDM Nasir, JCT Lim, ... Journal of clinical pathology 68 (9), 685-691, 2015 | 80 | 2015 |
The landscape of tolerated genetic variation in humans and primates H Gao, T Hamp, J Ede, JG Schraiber, J McRae, M Singer-Berk, Y Yang, ... Science 380 (6648), eabn8153, 2023 | 69 | 2023 |
A global catalog of whole-genome diversity from 233 primate species LFK Kuderna, H Gao, MC Janiak, M Kuhlwilm, JD Orkin, T Bataillon, ... Science 380 (6648), 906-913, 2023 | 69 | 2023 |
Beyond fitness tracking: the use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research WK Lim, S Davila, JX Teo, C Yang, CJ Pua, C Blöcker, JQ Lim, J Ching, ... PLoS biology 16 (2), e2004285, 2018 | 69 | 2018 |
Germline mutations in cancer predisposition genes are frequent in sporadic sarcomas SH Chan, WK Lim, NDB Ishak, ST Li, WL Goh, GS Tan, KH Lim, M Teo, ... Scientific Reports 7 (1), 10660, 2017 | 69 | 2017 |