| The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I) G Multhaup, A Schlicksupp, L Hesse, D Beher, T Ruppert, CL Masters, ... Science 271 (5254), 1406-1409, 1996 | 845 | 1996 |
| Resveratrol is not a direct activator of SIRT1 enzyme activity D Beher, J Wu, S Cumine, KW Kim, SC Lu, L Atangan, M Wang Chemical biology & drug design 74 (6), 619-624, 2009 | 540 | 2009 |
| L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity MS Shearman, D Beher, EE Clarke, HD Lewis, T Harrison, P Hunt, ... Biochemistry 39 (30), 8698-8704, 2000 | 517 | 2000 |
| The βA4 amyloid precursor protein binding to copper L Hesse, D Beher, CL Masters, G Multhaup FEBS letters 349 (1), 109-116, 1994 | 327 | 1994 |
| Reactive oxygen species and Alzheimer's disease G Multhaup, T Ruppert, A Schlicksupp, L Hesse, D Beher, CL Masters, ... Biochemical pharmacology 54 (5), 533-539, 1997 | 305 | 1997 |
| Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease S Scheuermann, B Hambsch, L Hesse, J Stumm, C Schmidt, D Beher, ... Journal of Biological Chemistry 276 (36), 33923-33929, 2001 | 281 | 2001 |
| Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders NJ Brandon, EJ Handford, I Schurov, JC Rain, M Pelling, B Duran-Jimeniz, ... Molecular and cellular neuroscience 25 (1), 42-55, 2004 | 279 | 2004 |
| Selected non-steroidal anti-inflammatory drugs and their derivatives target γ-secretase at a novel site: evidence for an allosteric mechanism D Beher, EE Clarke, JDJ Wrigley, ACL Martin, A Nadin, I Churcher, ... Journal of Biological Chemistry 279 (42), 43419-43426, 2004 | 256 | 2004 |
| Regulation of amyloid protein precursor (APP) binding to Collagen and mapping of the binding sites on APP and collagen type I (∗) D Beher, L Hesse, CL Masters, G Multhaup Journal of biological chemistry 271 (3), 1613-1620, 1996 | 243 | 1996 |
| Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease S Weggen, D Beher Alzheimer's research & therapy 4, 1-14, 2012 | 224 | 2012 |
| Quantification of Alzheimer pathology in ageing and dementia: age‐related accumulation of amyloid‐β (42) peptide in vascular dementia H Lewis, D Beher, N Cookson, A Oakley, M Piggott, CM Morris, E Jaros, ... Neuropathology and applied neurobiology 32 (2), 103-118, 2006 | 212 | 2006 |
| Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling HD Lewis, M Leveridge, PR Strack, CD Haldon, J O'neil, H Kim, A Madin, ... Chemistry & biology 14 (2), 209-219, 2007 | 178 | 2007 |
| γ-Secretase complex assembly within the early secretory pathway A Capell, D Beher, S Prokop, H Steiner, C Kaether, MS Shearman, ... Journal of Biological Chemistry 280 (8), 6471-6478, 2005 | 130 | 2005 |
| Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity D Beher, JDJ Wrigley, AP Owens, MS Shearman Journal of neurochemistry 82 (3), 563-575, 2002 | 130 | 2002 |
| Pharmacological knock-down of the presenilin 1 heterodimer by a novel γ-secretase inhibitor: implications for presenilin biology D Beher, JDJ Wrigley, A Nadin, G Evin, CL Masters, T Harrison, JL Castro, ... Journal of Biological Chemistry 276 (48), 45394-45402, 2001 | 127 | 2001 |
| C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation J Wang, D Beher, AC Nyborg, MS Shearman, TE Golde, A Goate Journal of neurochemistry 96 (1), 218-227, 2006 | 114 | 2006 |
| Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production M Dimitrov, JR Alattia, T Lemmin, R Lehal, A Fligier, J Houacine, ... Nature communications 4 (1), 2246, 2013 | 110 | 2013 |
| LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease J Majercak, WJ Ray, A Espeseth, A Simon, XP Shi, C Wolffe, K Getty, ... Proceedings of the National Academy of Sciences 103 (47), 17967-17972, 2006 | 110 | 2006 |
| In vitro characterization of the presenilin-dependent γ-secretase complex using a novel affinity ligand D Beher, M Fricker, A Nadin, EE Clarke, JDJ Wrigley, YM Li, JG Culvenor, ... Biochemistry 42 (27), 8133-8142, 2003 | 101 | 2003 |
| The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain SF Lichtenthaler, D Beher, HS Grimm, R Wang, MS Shearman, ... Proceedings of the National Academy of Sciences 99 (3), 1365-1370, 2002 | 88 | 2002 |
