| DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration J Irianto, Y Xia, CR Pfeifer, A Athirasala, J Ji, C Alvey, M Tewari, ... Current biology 27 (2), 210-223, 2017 | 281 | 2017 |
| Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest S Cho, M Vashisth, A Abbas, S Majkut, K Vogel, Y Xia, IL Ivanovska, ... Developmental cell 49 (6), 920-935. e5, 2019 | 250 | 2019 |
| Mechanotransduction in cancer LK Chin, Y Xia, DE Discher, PA Janmey Current opinion in chemical engineering 11, 77-84, 2016 | 190 | 2016 |
| Nuclear rupture at sites of high curvature compromises retention of DNA repair factors Y Xia, IL Ivanovska, K Zhu, L Smith, J Irianto, CR Pfeifer, CM Alvey, J Ji, ... Journal of Cell Biology 217 (11), 3796-3808, 2018 | 164 | 2018 |
| Nuclear constriction segregates mobile nuclear proteins away from chromatin J Irianto, CR Pfeifer, RR Bennett, Y Xia, IL Ivanovska, AJ Liu, ... Molecular biology of the cell 27 (25), 4011-4020, 2016 | 130 | 2016 |
| SIRPA-inhibited, marrow-derived macrophages engorge, accumulate, and differentiate in antibody-targeted regression of solid tumors CM Alvey, KR Spinler, J Irianto, CR Pfeifer, B Hayes, Y Xia, S Cho, ... Current Biology 27 (14), 2065-2077. e6, 2017 | 124 | 2017 |
| Accurate genomic variant detection in single cells with primary template-directed amplification V Gonzalez-Pena, S Natarajan, Y Xia, D Klein, R Carter, Y Pang, ... Proceedings of the National Academy of Sciences 118 (24), e2024176118, 2021 | 115 | 2021 |
| Constricted migration increases DNA damage and independently represses cell cycle CR Pfeifer, Y Xia, K Zhu, D Liu, J Irianto, VMM García, LMS Millán, ... Molecular biology of the cell 29 (16), 1948-1962, 2018 | 115 | 2018 |
| Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle Y Xia, CR Pfeifer, K Zhu, J Irianto, D Liu, K Pannell, EJ Chen, LJ Dooling, ... Journal of Cell Biology 218 (8), 2545-2563, 2019 | 88 | 2019 |
| SnapShot: mechanosensing matrix J Irianto, CR Pfeifer, Y Xia, DE Discher Cell 165 (7), 1820-1820. e1, 2016 | 63 | 2016 |
| As a nucleus enters a small pore, chromatin stretches and maintains integrity, even with DNA breaks J Irianto, Y Xia, CR Pfeifer, RA Greenberg, DE Discher Biophysical journal 112 (3), 446-449, 2017 | 59 | 2017 |
| Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A, C in iPS-derived mesenchymal stem cells S Cho, A Abbas, J Irianto, IL Ivanovska, Y Xia, M Tewari, DE Discher Nucleus 9 (1), 235-250, 2018 | 38 | 2018 |
| Constricted migration modulates stem cell differentiation LR Smith, J Irianto, Y Xia, CR Pfeifer, DE Discher Molecular biology of the cell 30 (16), 1985-1999, 2019 | 34 | 2019 |
| Nuclear mechanics during and after constricted migration Y Xia, CR Pfeifer, DE Discher Acta Mechanica Sinica 35, 299-308, 2019 | 33 | 2019 |
| Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review CR Pfeifer, M Vashisth, Y Xia, DE Discher Essays in Biochemistry 63 (5), 569-577, 2019 | 29 | 2019 |
| Nuclear mechanosensing Y Xia, CR Pfeifer, S Cho, DE Discher, J Irianto Emerging topics in life sciences 2 (5), 713-725, 2018 | 25 | 2018 |
| Elastic-fluid model for DNA damage and mutation from nuclear fluid segregation due to cell migration RR Bennett, CR Pfeifer, J Irianto, Y Xia, DE Discher, AJ Liu Biophysical journal 112 (11), 2271-2279, 2017 | 24 | 2017 |
| Scaling concepts in ‘omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis M Vashisth, S Cho, J Irianto, Y Xia, M Wang, B Hayes, D Wieland, R Wells, ... Proceedings of the National Academy of Sciences 118 (48), e2112940118, 2021 | 17 | 2021 |
| Multivalent, soluble nano-self peptides increase phagocytosis of antibody-opsonized targets while suppressing “Self” signaling AAR Jalil, BH Hayes, JC Andrechak, Y Xia, DM Chenoweth, DE Discher ACS nano 14 (11), 15083-15093, 2020 | 15 | 2020 |
| Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors J Irianto, CR Pfeifer, Y Xia, A Athirasala, IL Ivanovska, RA Greenberg, ... bioRxiv, 035626, 2015 | 14 | 2015 |
Dennis DischerUniversity of PennsylvaniaVerified email at seas.upenn.edu