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Large conserved domains of low DNA methylation maintained by Dnmt3a
M Jeong, D Sun, M Luo, Y Huang, GA Challen, B Rodriguez, X Zhang, ...
Nature genetics 46 (1), 17-23, 2014
Mandates: US National Institutes of Health, UK Biotechnology and Biological Sciences …
The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends
X Chen, D Cui, A Papusha, X Zhang, CD Chu, J Tang, K Chen, X Pan, ...
Nature 489 (7417), 576-580, 2012
Mandates: US National Institutes of Health
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
X Zhang, J Su, M Jeong, M Ko, Y Huang, HJ Park, A Guzman, Y Lei, ...
Nature genetics 48 (9), 1014-1023, 2016
Mandates: US National Institutes of Health, Wellcome Trust
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein
Y Lei, X Zhang, J Su, M Jeong, MC Gundry, YH Huang, Y Zhou, W Li, ...
Nature communications 8 (1), 16026, 2017
Mandates: US National Institutes of Health
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A
YH Huang, J Su, Y Lei, L Brunetti, MC Gundry, X Zhang, M Jeong, W Li, ...
Genome biology 18, 1-11, 2017
Mandates: US National Institutes of Health
Long non-coding RNAs control hematopoietic stem cell function
M Luo, M Jeong, D Sun, HJ Park, BAT Rodriguez, Z Xia, L Yang, X Zhang, ...
Cell stem cell 16 (4), 426-438, 2015
Mandates: US National Institutes of Health
DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias
L Yang, B Rodriguez, A Mayle, HJ Park, X Lin, M Luo, M Jeong, CV Curry, ...
Cancer cell 29 (6), 922-934, 2016
Mandates: US National Institutes of Health, Cancer Research UK, UK Medical Research …
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart
A Karlstaedt, X Zhang, H Vitrac, R Harmancey, H Vasquez, JH Wang, ...
Proceedings of the National Academy of Sciences 113 (37), 10436-10441, 2016
Mandates: US National Institutes of Health
Homeobox oncogene activation by pan-cancer DNA hypermethylation
J Su, YH Huang, X Cui, X Wang, X Zhang, Y Lei, J Xu, X Lin, K Chen, J Lv, ...
Genome biology 19, 1-12, 2018
Mandates: US National Institutes of Health, Chinese Academy of Sciences
Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance
H Wang, W Wu, HW Wang, S Wang, Y Chen, X Zhang, J Yang, S Zhao, ...
Neuro-oncology 12 (7), 679-686, 2010
Mandates: US National Institutes of Health
Large DNA methylation nadirs anchor chromatin loops maintaining hematopoietic stem cell identity
X Zhang, M Jeong, X Huang, XQ Wang, X Wang, W Zhou, MS Shamim, ...
Molecular cell 78 (3), 506-521. e6, 2020
Mandates: US National Science Foundation, US National Institutes of Health, Cancer …
MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1
R Zhang, H Luo, S Wang, W Chen, Z Chen, HW Wang, Y Chen, J Yang, ...
Neuro-oncology 16 (11), 1510-1522, 2014
Mandates: National Natural Science Foundation of China
VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells
Y Chen, D Meng, H Wang, R Sun, D Wang, S Wang, J Fan, Y Zhao, ...
Neuro-oncology 17 (3), 407-418, 2015
Mandates: National Natural Science Foundation of China
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, ...
Nature chemical biology 17 (7), 784-793, 2021
Mandates: US Department of Energy, US National Institutes of Health
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis
X Zhang, X Wang, XQD Wang, J Su, N Putluri, T Zhou, Y Qu, M Jeong, ...
Blood, The Journal of the American Society of Hematology 135 (11), 845-856, 2020
Mandates: US National Institutes of Health, Wellcome Trust, Cancer Prevention Research …
Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia
XQD Wang, D Fan, Q Han, Y Liu, H Miao, X Wang, Q Li, D Chen, H Gore, ...
Cancer discovery 13 (3), 724-745, 2023
Mandates: US National Institutes of Health, V Foundation, USA
Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies
H Zeng, H He, L Guo, J Li, M Lee, W Han, AG Guzman, S Zang, Y Zhou, ...
Cancer letters 467, 1-8, 2019
Mandates: US National Institutes of Health, Cancer Prevention Research Institute of …
Connecting high-resolution 3D chromatin organization with epigenomics
F Feng, Y Yao, XQD Wang, X Zhang, J Liu
Nature communications 13 (1), 2054, 2022
Mandates: US National Institutes of Health
A cell type-specific class of chromatin loops anchored at large DNA methylation nadirs
M Jeong, X Huang, X Zhang, J Su, MS Shamim, ID Bochkov, J Reyes, ...
Biorxiv, 212928, 2017
Mandates: US National Science Foundation, US National Institutes of Health
3′ HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
P Himadewi, XQD Wang, F Feng, H Gore, Y Liu, L Yu, R Kurita, ...
Elife 10, e70557, 2021
Mandates: US National Institutes of Health
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