| Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress E Kubo, B Chhunchha, P Singh, H Sasaki, DP Singh Scientific reports 7 (1), 14130, 2017 | 201 | 2017 |
| Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation B Chhunchha, N Fatma, E Kubo, P Rai, SP Singh, DP Singh American Journal of Physiology-Cell Physiology 304 (7), C636-C655, 2013 | 112 | 2013 |
| Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage R Tulsawani, LS Kelly, N Fatma, B Chhunchha, E Kubo, A Kumar, ... BMC neuroscience 11, 1-13, 2010 | 81 | 2010 |
| Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid MV Rao, B Chhunchha Food and chemical toxicology 48 (1), 7-10, 2010 | 80 | 2010 |
| Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress B Chhunchha, N Fatma, B Bhargavan, E Kubo, A Kumar, DP Singh Cell death & disease 2 (11), e234-e234, 2011 | 64 | 2011 |
| Clock protein Bmal1 and Nrf2 cooperatively control aging or oxidative response and redox homeostasis by regulating rhythmic expression of Prdx6 B Chhunchha, E Kubo, DP Singh Cells 9 (8), 1861, 2020 | 63 | 2020 |
| Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis N Fatma, P Singh, B Chhunchha, E Kubo, T Shinohara, B Bhargavan, ... American Journal of Physiology-Cell Physiology 301 (4), C954-C967, 2011 | 58 | 2011 |
| Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells SP Singh, B Chhunchha, N Fatma, E Kubo, SP Singh, DP Singh American Journal of Physiology-Cell Physiology 310 (1), C1-C16, 2016 | 56 | 2016 |
| Prdx6 retards senescence and restores trabecular meshwork cell health by regulating reactive oxygen species B Chhunchha, P Singh, WD Stamer, DP Singh Cell death discovery 3 (1), 1-12, 2017 | 47 | 2017 |
| Sulforaphane-induced Klf9/Prdx6 axis acts as a molecular switch to control redox signaling and determines fate of cells B Chhunchha, E Kubo, DP Singh Cells 8 (10), 1159, 2019 | 41 | 2019 |
| LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway B Bhargavan, N Fatma, B Chhunchha, V Singh, E Kubo, DP Singh Cell death & disease 3 (5), e316-e316, 2012 | 39 | 2012 |
| Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter DP Singh, B Bhargavan, B Chhunchha, E Kubo, A Kumar, N Fatma PLoS One 7 (5), e37012, 2012 | 38 | 2012 |
| Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription B Chhunchha, N Fatma, E Kubo, DP Singh The FEBS journal 281 (15), 3357-3381, 2014 | 33 | 2014 |
| Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation B Chhunchha, E Kubo, N Fatma, DP Singh Cell Death & Disease 8 (1), e2525-e2525, 2018 | 29 | 2018 |
| Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress B Chhunchha, E Kubo, P Singh, DP Singh Aging (Albany NY) 10 (9), 2284, 2018 | 26 | 2018 |
| Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island B Bhargavan, B Chhunchha, N Fatma, E Kubo, A Kumar, DP Singh Epigenetics 8 (3), 268-280, 2013 | 20 | 2013 |
| Switching of redox signaling by Prdx6 expression decides cellular fate by hormetic phenomena involving Nrf2 and reactive oxygen species B Chhunchha, E Kubo, DP Singh Cells 11 (8), 1266, 2022 | 15 | 2022 |
| Lens epithelium‐derived growth factor deSumoylation by Sumo‐specific protease‐1 regulates its transcriptional activation of small heat shock protein and the cellular response K Ishihara, N Fatma, B Bhargavan, B Chhunchha, E Kubo, S Dey, ... The FEBS journal 279 (17), 3048-3070, 2012 | 14 | 2012 |
| Ginkgolic acid rescues lens epithelial cells from injury caused by redox regulated-aberrant sumoylation signaling by reviving Prdx6 and Sp1 expression and activities B Chhunchha, P Singh, DP Singh, E Kubo International journal of molecular sciences 19 (11), 3520, 2018 | 7 | 2018 |
| Obligatory role of AMPK activation and antioxidant defense pathway in the regulatory effects of metformin on cellular protection and prevention of lens opacity B Chhunchha, E Kubo, DP Singh Cells 11 (19), 3021, 2022 | 6 | 2022 |
Biju BhargavanPharmacology & Experimental Neurosciences, Universiy Of NebraskaVerified email at unmc.edu