Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by T Blundell, G Dodson, D Hodgkin, D Mercola Advances in protein chemistry 26, 279-402, 1972 | 1093 | 1972 |
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 T Smeal, B Binetruy, DA Mercola, M Birrer, M Karin Nature 354 (6353), 494-496, 1991 | 1006 | 1991 |
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling T Virolle, ED Adamson, V Baron, D Birle, D Mercola, T Mustelin, I de Belle Nature cell biology 3 (12), 1124-1128, 2001 | 515 | 2001 |
Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. H Fakhrai, O Dorigo, DL Shawler, H Lin, D Mercola, KL Black, I Royston, ... Proceedings of the National Academy of Sciences 93 (7), 2909-2914, 1996 | 461 | 1996 |
The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and fibronectin V Baron, ED Adamson, A Calogero, G Ragona, D Mercola Cancer gene therapy 13 (2), 115-124, 2006 | 451 | 2006 |
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 T Smeal, B Binetruy, D Mercola, A Grover-Bardwick, G Heidecker, ... Molecular and Cellular Biology 12 (8), 3507-3513, 1992 | 425 | 1992 |
Atomic positions in rhombohedral 2-zinc insulin crystals TL Blundell, JF Cutfield, SM Cutfield, EJ Dodson, GG Dodson, ... Nature 231 (5304), 506-511, 1971 | 411 | 1971 |
Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer S Khan, JMS Jutzy, MMA Valenzuela, D Turay, JR Aspe, A Ashok, ... Public Library of Science 7 (10), e46737, 2012 | 368 | 2012 |
Structure of insulin in 4-zinc insulin G Bentley, E Dodson, GUY Dodson, D Hodgkin, DAN Mercola Nature 261 (5556), 166-168, 1976 | 346 | 1976 |
Decreased Egr‐1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation RP Huang, Y Fan, I De Belle, C Niemeyer, MM Gottardis, D Mercola, ... International journal of cancer 72 (1), 102-109, 1997 | 323 | 1997 |
Suppression of growth and transformation and induction of apoptosis by EGR-1. C Liu, VM Rangnekar, E Adamson, D Mercola Cancer gene therapy 5 (1), 3-28, 1998 | 306 | 1998 |
The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin O Potapova, A Haghighi, F Bost, C Liu, MJ Birrer, R Gjerset, D Mercola Journal of Biological Chemistry 272 (22), 14041-14044, 1997 | 292 | 1997 |
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors J Qi, K Nakayama, RD Cardiff, AD Borowsky, K Kaul, R Williams, ... Cancer cell 18 (1), 23-38, 2010 | 252 | 2010 |
In silico dissection of cell-type-associated patterns of gene expression in prostate cancer RO Stuart, W Wachsman, CC Berry, J Wang-Rodriguez, L Wasserman, ... Proceedings of the National Academy of Sciences 101 (2), 615-620, 2004 | 250 | 2004 |
Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress J Hayakawa, S Mittal, Y Wang, KS Korkmaz, E Adamson, C English, ... Molecular cell 16 (4), 521-535, 2004 | 249 | 2004 |
Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer … J Hayakawa, M Ohmichi, H Kurachi, H Ikegami, A Kimura, T Matsuoka, ... Journal of Biological Chemistry 274 (44), 31648-31654, 1999 | 237 | 1999 |
Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines Y Li, B Lin, A Agadir, R Liu, MI Dawson, JC Reed, JA Fontana, F Bost, ... Molecular and cellular biology 18 (8), 4719-4731, 1998 | 219 | 1998 |
Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1. C Liu, E Adamson, D Mercola Proceedings of the National Academy of Sciences 93 (21), 11831-11836, 1996 | 209 | 1996 |
The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA … J Hayakawa, C Depatie, M Ohmichi, D Mercola Journal of Biological Chemistry 278 (23), 20582-20592, 2003 | 206 | 2003 |
Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain RP Huang, C Liu, Y Fan, D Mercola, ED Adamson Cancer research 55 (21), 5054-5062, 1995 | 201 | 1995 |